PF3D7_0100300 (VAR)

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Non - Mutable in CDS

• Mutagenesis Index Score (MIS): 0.663
• Mutagenesis Fitness Score (MFS): -2.461
• Number of insertions in CDS: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NFB4

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=0.28) with 5MZA (Global RMSD=4.83)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Protein Information

Protein length: 1327 | Molecular Weight (kDa): 153.32

UniProt ID(s): A0A0F6P8H0, A0A5P1A0B7, A0A5P1A0V6, A0A5P1A1A1, A0A5P1A1D6, A0A5P1A1K6, A0A5P1A1L4, A0A5P1A2K8, A1KQT3, A3R6U7, Q1KV45, Q1KV46, Q1KVF5, Q9NFB4

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0100300

Resistome Missense Mutations: Y137F, N145H, H147D, V1222I

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 1093

Non-coding: 21 | Synonymous: 414 | Nonsynonymous: 641 | Stop Codon: 17

Associated Publications