Genomic location: Pf3D7_02_v3:38,287..39,303(-)
Miles Classification: SubtelomericHypervariable
Product Description: stevor
SignalP Peptide: MKMYYLKMLLFTFLINTLVA
# Transmembrane Domains: 2
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020036 | Maurer's cleft |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96111
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 304 | Molecular Weight (kDa): 34.425
PDB ID(s): None
Isoelectric Point: 9.51
Protein Domain Annotations:
| InterPro | IPR006374 | Variant surface antigen Stevor |
| PFam | PF17410 | Variant surface antigen Stevor |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0200400
Resistome Missense Mutations: I157F, A160T, E163D, E163A
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 456
Non-coding: 46 | Synonymous: 116 | Nonsynonymous: 290 | Stop Codon: 4
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 12477793 | Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. | Kaviratne M, Khan SM, Jarra W, Preiser PR | 10.1128/EC.1.6.926-935.2002 |
| 15961998 | Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infectederythrocytes. | Przyborski JM, Miller SK, ..., Lanzer M | 10.1038/sj.emboj.7600720 |
| 25011110 | STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. | Niang M, Bei AK, ..., Preiser PR | 10.1016/j.chom.2014.06.004 |