Genomic location: Pf3D7_02_v3:411,419..412,963(+)
Miles Classification: Core
Product Description: 60S ribosomal protein L37ae, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005634 | nucleus |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 2.72 | Trophozoite: 2.47 | Schizont: 0 | Gametocyte: 1.46
More info:
Zhang Phenotype: Non - Mutable in CDS *tentative
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZYX3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100717
Most Similar Human Ortholog: Q6P4E4
All Human Orthologs (OrthoMCL):
| ENSG00000197756 | ribosomal protein L37a |
Protein length: 96 | Molecular Weight (kDa): 10.799
UniProt ID(s): A0A143ZYX3, O96184
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.2
Protein Domain Annotations:
| InterPro | IPR002674 | Ribosomal protein L37ae |
| InterPro | IPR011332 | Zinc-binding ribosomal protein |
| PFam | PF01780 | Ribosomal protein L37ae |
| Superfamily | SSF57829 | Zinc-binding ribosomal protein |
Old (Pf3D7v3) Gene ID: PF3D7_0210100.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 3 | 6 | 6 |
| disruptive | 0 | 2 | 1 | 6 |
| missense | 0 | 2 | 1 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 6 | 7 |
| disruptive | 0 | 9 | 4 | 16 |
| missense | 0 | 4 | 3 | 9 |
PlasmoDB Total SNPs: 42
Non-coding: 38 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 36035163 | Identification of pathogenic genes associated with CKD: An integratedbioinformatics approach | Ahmed MM, Shafat Z, ..., Ishrat R | 10.3389/fgene.2022.891055 |
| 31901916 | Selection of reference genes for quantitative studies in acute myeloid leukaemia | Lee C, Yiau KXS, ..., Abdullah M | |
| 36194357 | Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic OvarySyndrome Mouse Model: Differential Gene Expression Analysis of Oocytes | Nakanishi N, Osuka S, ..., Kajiyama H | 10.1007/s43032-022-01095-7 |
| 35830453 | Identification of the shared gene signatures and pathways between polycysticovary syndrome and endometrial cancer: An omics data based combined approach | Miao C, Chen Y, ..., Zhang Q | 10.1371/journal.pone.0271380 |
| 27871894 | Optimizing gDNA extraction from fresh frozen meningioma tissue for downstreamgenetic analysis | Proctor DT, Yoo EH, ..., Sutherland GR | 10.1016/j.clinbiochem.2016.11.016 |
| 29294071 | Genetic Architecture and Selection of Chinese Cattle Revealed by Whole GenomeResequencing | Mei C, Wang H, ..., Zan L | 10.1093/molbev/msx322 |
| 32886018 | The Influence of Melatonin on the Daily 24-h Rhythm of Putative Reference GeneExpression in White Adipose Tissues | Figueira da Costa TN, Andreotti S, ..., Bargi-Souza P | 10.1177/0748730420949337 |
| 32255771 | Sex Differences in Osteoarthritis Pathogenesis: A Comprehensive Study Based onBioinformatics | Yang Y, You X, ..., Yu T | 10.12659/MSM.923331 |
| 36184577 | Selection and validation of reference genes for qPCR analysis of differentiationand maturation of THP-1 cells into M1 macrophage-like cells | Ren G, Juhl M, ..., Porsborg SR | 10.1111/imcb.12590 |
| 32729067 | Assessing and validating housekeeping genes in normal, cancerous, and polycystichuman ovaries | Asiabi P, Ambroise J, ..., Amorim CA | 10.1007/s10815-020-01901-8 |
| 29702086 | Melatonin decreases neuronal excitability in a sub-population of dorsal rootganglion neurons | Oliveira-Abreu K, Ferreira-da-Silva FW, ..., Leal-Cardoso JH | 10.1016/j.brainres.2018.04.027 |
| 32951185 | Analysis of RPL37A, MTSS1, and HTRA1 expression as potential markers forpathologic complete response and survival | Carrara GFA, Evangelista AF, ..., da Costa Vieira RA | 10.1007/s12282-020-01159-z |
| 29344651 | Identification of genes and pathways in the synovia of women with osteoarthritisby bioinformatics analysis | Mi B, Liu G, ..., Liu J | 10.3892/mmr.2018.8429 |
| 37946148 | Construction of disulfidptosis-related lncRNA signature for predicting theprognosis and immune escape in colon adenocarcinoma | Chen P, Yu J, ..., Wang W | 10.1186/s12876-023-03020-x |
| 37091794 | Bioinformatics analysis based on crucial genes of endothelial cells inrheumatoid | Zhou X, Wu L | 10.3389/fgene.2023.1143644 |
| 35282067 | Identification of a seven-gene prognostic signature using the gene expressionprofile of osteosarcoma | Liu Z, Zhong Y, ..., Chen W | 10.21037/atm-21-6276 |
| 31997824 | Expression of long non-coding RNAs in complete transection spinal cord injury: atranscriptomic analysis | Ding L, Fu WJ, ..., Wu HF | 10.4103/1673-5374.274348 |
| 28039034 | Development and evaluation of a novel RT-qPCR based test for the quantificationof HER2 gene expression in breast cancer | El Hadi H, Abdellaoui-Maane I, ..., Moumen A | 10.1016/j.gene.2016.12.027 |
| 29665991 | Differential proteomic analysis of actinic keratosis, Bowen's disease andcutaneous squamous cell carcinoma by label-free LC-MS/MS | Azimi A, Kaufman KL, ..., Fernandez-Penas P | 10.1016/j.jdermsci.2018.04.006 |
| 28886093 | Comparison of risk classification between EndoPredict and MammaPrint inER-positive/HER2-negative primary invasive breast cancer | Pelaez-Garcia A, Yebenes L, ..., Hardisson D | 10.1371/journal.pone.0183452 |