About Gene List Toggle Layout

PF3D7_0308300 (PIC4)

Genomic location: Pf3D7_03_v3:365,177..366,948(-)

Miles Classification: Core

Function and Localization

Product Description: PhIL1-interacting candidate PIC4

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Component GO:0009986 cell surface
Component GO:0070258 inner membrane pellicle complex

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77324

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532669

No human ortholog(s)

Protein Information

Protein length: 337 | Molecular Weight (kDa): 38.944

UniProt ID(s): O77324

PDB ID(s): None

Isoelectric Point: 4.97

Protein Domain Annotations:

InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0308300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 22 15 30
disruptive 10 37 18 55
missense 10 37 17 46

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 50 12 16
disruptive 22 84 45 100
missense 18 74 39 57

PlasmoDB Total SNPs: 91

Non-coding: 71 | Synonymous: 7 | Nonsynonymous: 13 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341
37437395 Tailoring the band-gap, optical and fluorescent properties of 3,5-diaminobenzoicacid via functionalization with chemical groups: A DFT study Anyama CA, Inah B, Utsu P, Ayi AA 10.1016/j.talanta.2023.124777