Genomic location: Pf3D7_03_v3:465,745..468,557(+)
Miles Classification: Core
Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005634 | nucleus |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77357
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=18.35) with 7WM6 (Global RMSD=21.24)
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 786 | Molecular Weight (kDa): 92.848
UniProt ID(s): O77357
PDB ID(s): None
Isoelectric Point: 6.69
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0310900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 30 | 16 | 40 |
| disruptive | 16 | 74 | 53 | 133 |
| missense | 10 | 60 | 42 | 115 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 71 | 19 | 46 |
| disruptive | 32 | 169 | 90 | 223 |
| missense | 20 | 138 | 75 | 167 |
PlasmoDB Total SNPs: 113
Non-coding: 40 | Synonymous: 47 | Nonsynonymous: 26 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |