Genomic location: Pf3D7_03_v3:782,940..787,364(-)
Miles Classification: Core
Product Description: cleavage and polyadenylation specificity factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0006379 | mRNA cleavage |
| Process | GO:0006378 | mRNA polyadenylation |
| Process | GO:0016180 | snRNA processing |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 1.81 | Trophozoite: 0 | Schizont: 0 | Gametocyte: 0
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0806600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0806600)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77371
"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.11) with 3IEL (Global RMSD=1.57)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102863
Most Similar Human Ortholog: E9PNH9
All Human Orthologs (OrthoMCL):
| ENSG00000127054 | integrator complex subunit 11 |
Protein length: 1017 | Molecular Weight (kDa): 118.851
UniProt ID(s): O77371
PDB ID(s): None
Isoelectric Point: 8.36
Protein Domain Annotations:
| InterPro | IPR001279 | Metallo-beta-lactamase |
| InterPro | IPR011108 | Zn-dependent metallo-hydrolase, RNA specificity domain |
| InterPro | IPR022712 | Beta-Casp domain |
| InterPro | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
| PFam | PF07521 | Zn-dependent metallo-hydrolase, RNA specificity domain |
| PFam | PF10996 | Beta-Casp domain |
| PFam | PF16661 | Metallo-beta-lactamase |
| Superfamily | SSF56281 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Old (Pf3D7v3) Gene ID: PF3D7_0318600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 36 | 28 | 69 |
| disruptive | 14 | 75 | 54 | 132 |
| missense | 10 | 66 | 49 | 116 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 97 | 35 | 71 |
| disruptive | 35 | 178 | 107 | 226 |
| missense | 16 | 145 | 95 | 178 |
PlasmoDB Total SNPs: 133
Non-coding: 82 | Synonymous: 22 | Nonsynonymous: 28 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |