PF3D7_0419500

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Mutable in CDS

• Mutagenesis Index Score (MIS): 1
• Mutagenesis Fitness Score (MFS): -1.237
• Number of insertions in CDS: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1P2

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171398

No human ortholog(s)

Protein Information

Protein length: 536 | Molecular Weight (kDa): 63.995

UniProt ID(s): Q8I1P2

PDB ID(s): None

Isoelectric Point: 6.77

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0419500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 106

Non-coding: 84 | Synonymous: 11 | Nonsynonymous: 11 | Stop Codon: 0

Associated Publications