Genomic location: Pf3D7_04_v3:1,025,510..1,027,735(+)
Miles Classification: Core
Product Description: 40S ribosomal protein S19
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000028 | ribosomal small subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 3.00 | Trophozoite: 2.73 | Schizont: 1.05 | Gametocyte: 1.91
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IFP2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100904
Most Similar Human Ortholog: P39019
All Human Orthologs (OrthoMCL):
| ENSG00000105372 | ribosomal protein S19 |
Protein length: 170 | Molecular Weight (kDa): 19.722
UniProt ID(s): Q8IFP2
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.79
Protein Domain Annotations:
| InterPro | IPR001266 | Ribosomal protein S19e |
| InterPro | IPR018277 | Ribosomal protein S19e, conserved site |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF01090 | Ribosomal protein S19e |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_0422400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 6 | 9 |
| disruptive | 1 | 2 | 3 | 6 |
| missense | 1 | 2 | 3 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 10 | 6 |
| disruptive | 2 | 8 | 10 | 28 |
| missense | 2 | 6 | 8 | 22 |
PlasmoDB Total SNPs: 108
Non-coding: 102 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38002057 | Intercellular Molecular Crosstalk Networks within Invasive and ImmunosuppressiveTumor Microenvironment Subtypes Associated with Clinical Outcomes in Four CancerTypes | Wei J, Yu W, ..., Du H | 10.3390/biomedicines11113057 |
| 38116150 | Intrageneric structural variation in organelle genomes from the genus Dystaenia(Apiaceae): genome rearrangement and mitochondrion-to-plastid DNA transfer | Park S, Park S | 10.3389/fpls.2023.1283292 |
| 38336648 | Chloroplast genome analyses of Caragana arborescens and Caragana opulens | Liu L, Li H, ..., Zhou W | 10.1186/s12863-024-01202-4 |
| 37924024 | Complete mitogenome assembly of Selenicereus monacanthus revealed its molecularfeatures, genome evolution, and phylogenetic implications | Lu G, Wang W, ..., Que Y | 10.1186/s12870-023-04529-9 |
| 37376976 | Identification of novel mutations in patients with Diamond-Blackfan anemia andliterature review of RPS10 and RPS26 mutations | Li J, Su Y, ..., Ru K | 10.1111/ijlh.14126 |
| 38264024 | Complete mitochondrial genome of Syzygium samarangense reveals genomicrecombination, gene transfer, and RNA editing events | Lu G, Li Q | 10.3389/fpls.2023.1301164 |
| 38422566 | Circular RNA circRPS19 promotes chicken granulosa cell proliferation and steroidhormone synthesis by interrupting the miR-218-5p/INHBB axis | Wei Y, Shen X, ..., Yin H | 10.1016/j.theriogenology.2024.02.026 |
| 37822334 | Chloroplast genome assembly of Serjania erecta Raldk: comparative analysisreveals gene number variation and selection in protein-coding plastid genes ofSapindaceae | Corvalan LCJ, Sobreiro MB, ..., Nunes R | 10.3389/fpls.2023.1258794 |
| 37380816 | Complete chloroplast genome sequence of Camellia sinensis: genome structure,adaptive evolution, and phylogenetic relationships | Chen Z, Liu Q, ..., Gong Y | 10.1007/s13353-023-00767-7 |
| 38428846 | Role of Flt3l and Rps15 in ketamine anesthesia | Zhang L, Xu L | 10.1097/MD.0000000000037123 |
| 37894943 | Comparative Analysis of Plastomes in Elsholtzieae: Phylogenetic Relationships andPotential Molecular Markers | Tu XD, Zhao Z, ..., Chen SP | 10.3390/ijms242015263 |
| 37752993 | Hematopoietic cell transplantation and gene therapy for Diamond-Blackfan anemia:state of the art and science | Bhoopalan SV, Suryaprakash S, Sharma A, Wlodarski MW | 10.3389/fonc.2023.1236038 |
| 38263006 | Phylogeny and diversification of genus Sanicula L. (Apiaceae): novel insightsfrom plastid phylogenomic analyses | Song BN, Liu CK, ..., He XJ | 10.1186/s12870-024-04750-0 |
| 37560177 | Analysis of the complete plastomes of Albizia kalkora (Roxb.) Prain 1897(Fabaceae) | Yang H, Jiang M, ..., Liu C | 10.1080/23802359.2023.2241684 |
| 37520808 | Uncovering the first complete chloroplast genomics, comparative analysis, andphylogenetic relationships of the medicinal plants Rhamnus cathartica andFrangula alnus (Rhamnaceae) | Shi W, Hu S, ..., Wang S | 10.1007/s12298-023-01331-7 |
| 37566052 | DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and TumourGrowth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation ofWnt/Catenin Pathway | Vava A, Paccez JD, ..., Zerbini LF | 10.3390/cells12151973 |
| 37973818 | Perspectives of current understanding and therapeutics of Diamond-Blackfananemia | Liu Y, Karlsson S | 10.1038/s41375-023-02082-w |
| 37864923 | Comparative analysis of peripheral blood immunoinflammatory landscapes inpatients with acute cholangitis and its secondary septic shock using single-cellRNA sequencing | Zhang H, Wang N, ..., Zheng Y | 10.1016/j.bbrc.2023.149121 |
| 37897121 | Probable digenic inheritance of Diamond-Blackfan anemia | Furuta Y, Tinker RJ, ..., Phillips JA 3rd | 10.1002/ajmg.a.63454 |
| 37603219 | Establishment and characterization of CSCRi006-A: an induced pluripotent stemcell line generated from a patient with Diamond-Blackfan Anemia (DBA) carryingribosomal protein S19 (RPS19) mutation | Rani S, Thamodaran V, ..., Velayudhan SR | 10.1007/s13577-023-00946-y |