Product Description: DNA mismatch repair protein MSH6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0032301 | MutSalpha complex |
| Component | GO:0032300 | mismatch repair complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Function | GO:0003684 | damaged DNA binding |
| Function | GO:0000400 | four-way junction DNA binding |
| Function | GO:0030983 | mismatched DNA binding |
| Process | GO:0006281 | DNA repair |
| Process | GO:0036297 | interstrand cross-link repair |
| Process | GO:0043570 | maintenance of DNA repeat elements |
| Process | GO:0000710 | meiotic mismatch repair |
| Process | GO:0006298 | mismatch repair |
| Process | GO:0045910 | negative regulation of DNA recombination |
| Process | GO:0006290 | pyrimidine dimer repair |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505500
Resistome Missense Mutations: P462R
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.696 | MFS: -2.407 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I447
"Best" AlphaFill ligand hit: 3JD (niraparib, Local RMSD=0.11) with 7KK5 (Global RMSD=17.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100652
Most Similar Human Ortholog: A0A494C0M1
TM-align score: 0.70 | RMSD: 4.5
Seq Identity: 0.3 | Length: 979 / 1350
All Human Orthologs (OrthoMCL):
| ENSG00000116062 | mutS homolog 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 74 | 48 | 76 |
| disruptive | 21 | 69 | 53 | 100 |
| missense | 16 | 61 | 48 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 151 | 53 | 94 |
| disruptive | 42 | 160 | 89 | 198 |
| missense | 32 | 121 | 74 | 135 |
PlasmoDB Total SNPs: 157
Non-coding: 102 | Synonymous: 31 | Nonsynonymous: 23 | Stop Codon: 1
Protein length: 1350 | Molecular Weight (kDa): 156.44
UniProt ID(s): Q8I447
PDB ID(s): None
Isoelectric Point: 6.35
Protein Domain Annotations:
| InterPro | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| InterPro | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
| InterPro | IPR007696 | DNA mismatch repair protein MutS, core |
| InterPro | IPR007861 | DNA mismatch repair protein MutS, clamp |
| InterPro | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
| InterPro | IPR017261 | DNA mismatch repair protein MutS/MSH |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
| InterPro | IPR036678 | MutS, connector domain superfamily |
| PFam | PF00488 | DNA mismatch repair protein MutS, C-terminal |
| PFam | PF01624 | DNA mismatch repair protein MutS-like, N-terminal |
| PFam | PF05190 | DNA mismatch repair protein MutS, clamp |
| PFam | PF05192 | DNA mismatch repair protein MutS, core |
| Superfamily | SSF48334 | DNA mismatch repair protein MutS, core domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF53150 | MutS, connector domain superfamily |
| Superfamily | SSF55271 | DNA mismatch repair protein MutS, N-terminal |
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 38390329 | Mismatch repair gene MSH6 correlates with the prognosis, immune status and immunecheckpoint inhibitors response of endometrial cancer | Zhou LZ, Xiao HQ, Chen J | 10.3389/fimmu.2024.1302797 |
| 38394410 | Clinicopathological features and evaluation of microsatellite stability ofcolorectal carcinoma with cribriform comedo pattern | Gunler T, Karabagli P, ..., Korez MK | 10.4103/ijpm.ijpm_194_23 |
| 38350001 | Differential responses to immune checkpoint inhibitors are governed by diversemismatch repair gene alterations | Khushman MM, Toboni MD, ..., Powell MA | 10.1158/1078-0432.CCR-23-3004 |
| 38378964 | Predicting Mismatch Repair Deficiency Status in Endometrial Cancer throughMulti-Resolution Ensemble Learning in Digital Pathology | Whangbo J, Lee YS, ..., Kim KG | 10.1007/s10278-024-00997-z |
| 38404296 | Gastric and duodenal cancer in individuals with Lynch syndrome: a nationwidecohort study | Caspers IA, Eikenboom EL, ..., van Leerdam ME | 10.1016/j.eclinm.2024.102494 |
| 38310280 | Oligogenic basis of premature ovarian insufficiency: an observational study | Long P, Wang L, ..., Xiao H | 10.1186/s13048-024-01351-1 |
| 38297508 | Benign Adenomyoepithelioma: An Unrecognised Precursor of Ductal Carcinoma in Situin Patient With Lynch Syndrome | Park SS, Chan M, Velaiutham S, Vargas AC | 10.1177/10668969241226704 |
| 38297350 | Rare germline mutation and MSH2-&MSH6 + expression in a double primary carcinomaof colorectal carcinoma and endometrial carcinoma: a case report | Zhang T, Huang X, ..., Che S | 10.1186/s13000-024-01447-8 |
| 38423221 | Colorectal neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrineneoplasm: Prognostic factors and PD-L1 expression | Ho YH, Hsu CY, Yau Li AF, Liang WY | 10.1016/j.humpath.2024.02.012 |
| 38362598 | Integrated analyses of the genetic and clinicopathological features ofcholangiolocarcinoma: cholangiolocarcinoma may be characterized bymismatch-repair deficiency | Makino K, Ishii T, ..., Hatano E | 10.1002/path.6257 |
| 38298064 | Development of Complementary Photo-arginine/lysine to Promote Discovery ofArg/Lys hPTMs Interactomes | Zong Y, Weiss N, ..., Huang J | 10.1002/advs.202307526 |
| 38395750 | Association between colorectal cancer, the frequency of Bacteroides fragilis, andthe level of mismatch repair genes expression in the biopsy samples of Iranianpatients | Nazarinejad N, Hajikhani B, ..., Dadashi M | 10.1186/s12876-024-03169-z |
| 38415639 | Enterohemorrhagic Escherichia coli effector EspF triggers oxidative DNA lesionsin intestinal epithelial cells | Fang Y, Fu M, ..., Wan C | 10.1128/iai.00001-24 |
| 38315739 | Nonhomologous tails direct heteroduplex rejection and mismatch correction duringsingle-strand annealing in Saccharomyces cerevisiae | Sapede E, Sugawara N, ..., Haber JE | 10.1371/journal.pgen.1010527 |
| 38383663 | Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynchsyndrome | Dalene Skarping K, Arning L, ..., Gebre-Medhin S | 10.1038/s41598-024-54277-5 |
| 38401766 | Plant-specific environmental and developmental signals regulate the mismatchrepair protein MSH6 in Arabidopsis thaliana | Gonzalez V, Figueroa NR, Spampinato CP | 10.1016/j.plantsci.2024.112050 |
| 38416847 | Familial Intraductal Papillary Mucinous Neoplasm Associated With the GermlineMSH6 Missense Variant and Progression of Pancreatic cancer | Tezuka K, Yamakawa M, ..., Motoi F | 10.1097/MPA.0000000000002313 |
| 38302727 | The new 2023 F IGO staging system for endometrial cancer: what is different fromthe previous 2009 F IGO staging system? | Han KH, Park N, ..., Kim H | 10.3802/jgo.2024.35.e59 |
| 38295361 | Extra-Ocular Sebaceous Carcinoma in Situ of the Arm of an Elder Male: An UnusualPresentation in an Atypical Location | Shaker N, Sangueza OP, Shaker N, Pradhan D | 10.1177/10668969241226701 |
| 38295319 | Feasibility and Clinical Utility of Reporting Hereditary Cancer PredispositionPathogenic Variants Identified in Research Germline Sequencing: A ProspectiveInterventional Study | Hutchcraft ML, Zhang S, ..., Kolesar JM | 10.1200/PO.23.00266 |