Genomic location: Pf3D7_05_v3:251,337..253,815(-)
Miles Classification: Core
Product Description: small ubiquitin-related modifier
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0031386 | protein tag |
| Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Process | GO:0019941 | modification-dependent protein catabolic process |
| Process | GO:0016925 | protein sumoylation |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS *tentative
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I444
"Best" AlphaFill ligand hit: FMN (riboflavin monophosphate, Local RMSD=0.24) with 1Q45 (Global RMSD=15.35)
No associated EC numbersOrthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_100654
Most Similar Human Ortholog: J3KRH1
All Human Orthologs (OrthoMCL):
| ENSG00000116030 | small ubiquitin like modifier 1 |
| ENSG00000188612 | small ubiquitin like modifier 2 |
Protein length: 100 | Molecular Weight (kDa): 11.06
UniProt ID(s): Q8I444
PDB ID(s): None
Isoelectric Point: 4.51
Protein Domain Annotations:
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR022617 | Rad60/SUMO-like domain |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF11976 | Rad60/SUMO-like domain |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_0505800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 191
Non-coding: 188 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18547337 | Identification of a novel post-translational modification in Plasmodiumfalciparum: protein sumoylation in different cellular compartments. | Issar N, Roux E, Mattei D, Scherf A | 10.1111/j.1462-5822.2008.01183.x |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23943616 | Identification of biochemically distinct properties of the smallubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. | Reiter K, Mukhopadhyay D, ..., Matunis MJ | 10.1074/jbc.M113.498410 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 35331687 | Implications of critical node-dependent unidirectional cross-talk of PlasmodiumSUMO pathway proteins. | Singh JS, Sajeev T K, ..., Mishra RK | 10.1016/j.bpj.2022.03.022 |
| 38426545 | SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cellsby relying on the HIF‑1alpha signaling pathway | Qing Z, Luo Q, ..., Zeng Z | 10.3892/mmr.2024.13188 |
| 38389923 | Emerging role of SENP1 in tumorigenesis and cancer therapy | Lin M, Zhang M, ..., Li Z | 10.3389/fphar.2024.1354323 |
| 38408537 | PLA inhibits TNF-alpha-induced PANoptosis of prostate cancer cells through metabolicreprogramming | Hao Y, Xie F, ..., He J | 10.1016/j.biocel.2024.106554 |
| 38349439 | Comprehensive Analysis of the SUMO-related Signature: Implication for Diagnosis,Prognosis, and Immune Therapeutic Approaches in Cervical Cancer | Zhang X, Cao J, ..., Wang S | 10.1007/s10528-024-10728-2 |
| 38411156 | PML Nuclear bodies: the cancer connection and beyond | Abou-Ghali M, Lallemand-Breitenbach V | 10.1080/19491034.2024.2321265 |
| 38395307 | SUMO Modifies GbetaL and Mediates mTOR Signaling | Park SLL, Ramirez-Jarquin UN, ..., Subramaniam S | 10.1016/j.jbc.2024.105778 |
| 38420830 | MAVS Ubiquitylation: Function, Mechanism, and Beyond | Dong H, Shen J | 10.31083/j.fbl2902072 |
| 38407971 | The prognosis, chemotherapy and immunotherapy efficacy of the SUMOylation pathwaysignature and the role of UBA2 in lung adenocarcinoma | Yu L, Lin N, ..., Wang Q | 10.18632/aging.205594 |
| 38395208 | Effective expression and characterization of the receptor binding domains inSARS-CoV-2 Spike proteins from original strain and variants of concern usingBombyx mori nucleopolyhedrovirus in silkworm | Tsukamoto A, Jae Man L, ..., Kusakabe T | 10.1016/j.pep.2024.106450 |
| 38331013 | SENP3 attenuates foam cell formation by deSUMOylating NLRP3 in macrophagesstimulated with ox-LDL | Chen J, Sun X, ..., Shao L | 10.1016/j.cellsig.2024.111092 |
| 38340377 | RNF4 prevents genomic instability caused by chronic DNA under-replication | Oram MK, Baxley RM, ..., Bielinsky AK | 10.1016/j.dnarep.2024.103646 |
| 38343027 | COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-darkcycle in Arabidopsis | Lin WC, Chang HH, ..., Cheng MC | 10.1111/pce.14850 |
| 38335622 | Hypoxia causes trophoblast cell ferroptosis to induce miscarriage throughlnc-HZ06/HIF1alpha-SUMO/NCOA4 axis | Tian P, Xu Z, ..., Zhang H | 10.1016/j.redox.2024.103073 |
| 38372168 | HSV-1 ICP0 dimer domain adopts a novel beta-barrel fold | McCloskey E, Kashipathy M, ..., Davido DJ | 10.1002/prot.26673 |
| 38328138 | Topological regulation of the estrogen transcriptional response by ZATT-mediatedinhibition of TOP2B activity | Terron-Bautista J, Martinez-Sanchez MDM, ..., Cortes-Ledesma F | 10.1101/2024.01.22.576640 |
| 38326147 | SUMO proteases: from cellular functions to disease | Claessens LA, Vertegaal ACO | 10.1016/j.tcb.2024.01.002 |
| 38383667 | SENP3 mediates the activation of the Wnt/beta-catenin signaling pathway toaccelerate the growth and metastasis of oesophagal squamous cell carcinoma inmice | Wang P, Yang L, ..., Tian Z | 10.1007/s10142-024-01321-2 |
| 38338898 | An Efficient Expression and Purification Protocol for SpCas9 Nuclease andEvaluation of Different Delivery Methods of Ribonucleoprotein | Evmenov K, Pustogarov N, ..., Alkalaeva E | 10.3390/ijms25031622 |
| 38340040 | A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self-AssemblyMultivalent Scaffold LS-SUMO | Li Q, Zhang J, ..., Lu J | 10.1002/adhm.202303619 |
| 38351014 | ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastrictumor genesis and progression | Shi L, Shangguan J, ..., Shu X | 10.1186/s12967-024-04913-5 |