About Gene List Toggle Layout

PF3D7_0524100

Genomic location: Pf3D7_05_v3:1,002,547..1,008,230(+)

Miles Classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

N/A

Expression by stage, third quartile (Malaria Cell Atlas):

Ring: 2.40 | Trophozoite: 2.14 | Schizont: 0 | Gametocyte: 1.81

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3M4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532661

No human ortholog(s)

Protein Information

Protein length: 1243 | Molecular Weight (kDa): 147.819

UniProt ID(s): Q8I3M4

PDB ID(s): None

Isoelectric Point: 8.25

Protein Domain Annotations:

InterPro N/A N/A
PFam N/A N/A
Superfamily SSF101908 N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0524100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 65 51 82
disruptive 71 221 119 281
missense 48 196 100 235

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 132 58 98
disruptive 122 470 215 424
missense 80 372 177 250

PlasmoDB Total SNPs: 306

Non-coding: 142 | Synonymous: 85 | Nonsynonymous: 79 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095