PF3D7_0601000 (EPF4)

Function and Localization

Product Description: exported protein family 4

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Non - Mutable in CDS

• Mutagenesis Index Score (MIS): 0.151
• Mutagenesis Fitness Score (MFS): -3.167
• Number of insertions in CDS: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128062

No human ortholog(s)

Protein Information

Protein length: 309 | Molecular Weight (kDa): 35.714

UniProt ID(s): C0H4I0

PDB ID(s): None

Isoelectric Point: 10.2

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0601000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 70

Non-coding: 8 | Synonymous: 59 | Nonsynonymous: 3 | Stop Codon: 0

Associated Publications