Genomic location: Pf3D7_06_v3:115,789..118,379(+)
Miles Classification: Core
Product Description: JmjC domain-containing protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.14.11.27 ([Histone H3]-dimethyl-L-lysine(36) demethylase)
Curated GO (PlasmoDB):
| Function | GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0101600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0101600)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSM8
"Best" AlphaFill ligand hit: NO (nitric oxide, Local RMSD=0.09) with 4Z1V (Global RMSD=7.23)
BRENDA EC Inhibitors:
| 1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106314
Most Similar Human Ortholog: A2RUC4
All Human Orthologs (OrthoMCL):
| ENSG00000162971 | tRNA-yW synthesizing protein 5 |
Protein length: 646 | Molecular Weight (kDa): 77.767
UniProt ID(s): C6KSM8
PDB ID(s): None
Isoelectric Point: 10.21
Protein Domain Annotations:
| InterPro | IPR041667 | Cupin-like domain 8 |
| PFam | PF13621 | Cupin-like domain 8 |
| Superfamily | SSF51197 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0602800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 28 | 13 | 36 |
| disruptive | 27 | 86 | 48 | 109 |
| missense | 24 | 79 | 42 | 89 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 53 | 24 | 42 |
| disruptive | 50 | 207 | 85 | 185 |
| missense | 39 | 161 | 71 | 118 |
PlasmoDB Total SNPs: 115
Non-coding: 30 | Synonymous: 49 | Nonsynonymous: 35 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |