Genomic location: Pf3D7_07_v3:264,682..267,876(-)
Miles Classification: Core
Product Description: DNA replication licensing factor MCM7
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.4.12 (DNA helicase)
Curated GO (PlasmoDB):
| Component | GO:0042555 | MCM complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Function | GO:0003688 | DNA replication origin binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003697 | single-stranded DNA binding |
| Process | GO:0006270 | DNA replication initiation |
| Process | GO:0006271 | DNA strand elongation involved in DNA replication |
| Process | GO:0006268 | DNA unwinding involved in DNA replication |
| Process | GO:0000727 | double-strand break repair via break-induced replication |
| Process | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0803100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0805800)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC16
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.21) with 4R7Y (Global RMSD=8.91)
BRENDA EC Inhibitors:
| 3.6.4.12 | DNA helicase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102101
Most Similar Human Ortholog: C9J8M6
All Human Orthologs (OrthoMCL):
| ENSG00000166508 | minichromosome maintenance complex component 7 |
Protein length: 821 | Molecular Weight (kDa): 94.237
UniProt ID(s): Q8IC16
PDB ID(s): None
Isoelectric Point: 6.27
Protein Domain Annotations:
| InterPro | IPR001208 | MCM domain |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR008050 | DNA replication licensing factor Mcm7 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR018525 | Mini-chromosome maintenance, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR027925 | MCM N-terminal domain |
| InterPro | IPR031327 | Mini-chromosome maintenance protein |
| InterPro | IPR033762 | MCM OB domain |
| InterPro | IPR041562 | MCM, AAA-lid domain |
| PFam | PF00493 | MCM domain |
| PFam | PF14551 | MCM N-terminal domain |
| PFam | PF17207 | MCM OB domain |
| PFam | PF17855 | MCM, AAA-lid domain |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
Old (Pf3D7v3) Gene ID: PF3D7_0705400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 35 | 22 | 40 |
| disruptive | 6 | 17 | 17 | 45 |
| missense | 6 | 16 | 16 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 77 | 23 | 42 |
| disruptive | 6 | 54 | 38 | 112 |
| missense | 6 | 44 | 31 | 81 |
PlasmoDB Total SNPs: 81
Non-coding: 65 | Synonymous: 9 | Nonsynonymous: 7 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 16257456 | Pre-replication complex organization in the atypical DNA replication cycle ofPlasmodium falciparum: characterization of the mini-chromosome maintenance (MCM)complex formation. | Patterson S, Robert C, ..., Chakrabarti D | |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38423594 | CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival inPancreatic Adenocarcinoma | Tavlas P, Nikou S, ..., Bravou V | 10.21873/cgp.20438 |
| 37869664 | HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture forseasonal allergic rhinitis | Li L, Wen X, ..., Guan K | 10.3389/fmicb.2023.1202858 |
| 38182577 | WWOX promotes osteosarcoma development via upregulation of Myc | Akkawi R, Hidmi O, ..., Aqeilan RI | 10.1038/s41419-023-06378-8 |
| 38152742 | Retracted: High-Throughput Screening and Molecular Dynamics Simulation of NaturalProducts for the Identification of Anticancer Agents against MCM7 Protein | And Biomechanics AB | 10.1155/2023/9828706 |
| 38236723 | Decreased NSD2 impairs stromal cell proliferation in human endometrium viareprogramming H3K36me2 | Qin CM, Wei XW, ..., Lin Y | 10.1530/REP-23-0254 |
| 38104694 | Effects of geniposide on innate immunity and antiviral activity ofScyllaparamamosain | Gong J, Jin Q, Zhu F | 10.1016/j.fsi.2023.109303 |
| 37965327 | Single-cell transcriptomics reveals subtype-specific molecular profiles inNrf2-deficient macrophages from murine atherosclerotic aortas | Sarad K, Stefanska M, ..., Jazwa-Kusior A | 10.3389/fimmu.2023.1249379 |
| 38231525 | Heterogeneous Expression Patterns of the Minichromosome Maintenance ComplexMembers in Retinoblastoma Unveil Its Clinical Significance | Tang J, Liu Y, ..., Lu R | 10.1167/iovs.65.1.31 |
| 37844748 | Marine pollutant Phenanthrene (PHE) exposure causes immunosuppression ofhemocytes in crustacean species, Scylla paramamosain | Yifei Y, Zhixiong Z, ..., Xiujuan Z | 10.1016/j.cbpc.2023.109761 |
| 38254912 | Rare Deletions or Large Duplications Contribute to Genetic Variation in Patientswith Severe Tinnitus and Meniere Disease | Escalera-Balsera A, Parra-Perez AM, ..., Lopez-Escamez JA | 10.3390/genes15010022 |
| 38298573 | In search of lost ergots: phylogenetic re-evaluation of Claviceps species inJapan and their biogeographic patterns revealed | Tanaka E, Tanada K, ..., Liu M | 10.3114/sim.2023.106.01 |
| 37844854 | Paraphyly and cryptic diversity unveils unexpected challenges in the "nakedlichens" (Calvitimela, Lecanoromycetes, Ascomycota) | Fjelde MO, Timdal E, Haugan R, Bendiksby M | 10.1016/j.ympev.2023.107944 |
| 38312556 | Construction of immune-related molecular diagnostic and predictive models ofhepatocellular carcinoma based on machine learning | Zheng H, Han X, ..., Liu R | 10.1016/j.heliyon.2024.e24854 |
| 38181838 | Full-length transcriptomics study of Ustiloxins-induced hepatocyte injury | Zhang G, Zhou X, ..., Sun L | 10.1016/j.toxicon.2024.107604 |
| 38117512 | Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to DriveTumor Progression in Esophageal Cancer | Shi Q, Xu G, ..., Li F | 10.1158/0008-5472.CAN-23-1633 |
| 38298426 | RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liverhepatocellular carcinoma cells | Feng X, Song D, ..., Liu F | 10.3892/ol.2024.14238 |
| 37746211 | Hesperomyces (Fungi, Ascomycota) associated with Hyperaspis ladybirds(Coleoptera, Coccinellidae): Rethinking host specificity | Van Caenegem W, Ceryngier P, ..., Haelewaters D | 10.3389/ffunb.2022.1040102 |
| 38127629 | First Report of Erysiphe astragali Causing Powdery Mildew on Astragalusmongholicus in China | Wang YF, Yang JK, ..., Guo L | 10.1094/PDIS-09-23-1756-PDN |
| 37967729 | Effects of environmental pollutant benzop[alpha]yrene on the innate immunity ofScylla paramamosain and its mechanism | Geng P, Jin Q, Zhou X, Zhu F | 10.1016/j.fsi.2023.109228 |
| 37828936 | Phylogeny and species delimitations in the economically, medically, andecologically important genus Samsoniella (Cordycipitaceae, Hypocreales) | Wang Y, Wang ZQ, ..., Yu H | 10.3897/mycokeys.99.106474 |