Genomic location: Pf3D7_07_v3:695,091..697,180(-)
Miles Classification: Core
Product Description: drug/metabolite transporter DMT1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: 3.6.3.44 (Transferred entry: 7.6.2.2)
Curated GO (PlasmoDB):
| Component | GO:0016021 | integral component of membrane |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1422100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1422100)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBU2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 3.6.3.44 | xenobiotic-transporting ATPase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Protein length: 434 | Molecular Weight (kDa): 50.249
UniProt ID(s): Q8IBU2
PDB ID(s): None
Isoelectric Point: 9.09
Protein Domain Annotations:
| InterPro | IPR000620 | EamA domain |
| PFam | PF00892 | EamA domain |
| Superfamily | SSF103481 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0715800
Resistome Missense Mutations: M317L
Resistome Compounds with Missense Mutations: MMV674787
Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 8 | 23 |
| disruptive | 15 | 41 | 19 | 57 |
| missense | 13 | 38 | 17 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 56 | 14 | 27 |
| disruptive | 25 | 84 | 38 | 112 |
| missense | 21 | 70 | 25 | 75 |
PlasmoDB Total SNPs: 146
Non-coding: 111 | Synonymous: 17 | Nonsynonymous: 16 | Stop Codon: 2
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 38300967 | Identification of the reporter gene combination that shows high contrast forcellular level MRI | Hayashi N, Hata J, ..., Okano H | 10.1371/journal.pone.0297273 |
| 38146247 | Effect of electroacupuncture on oxidative stress and cell apoptosis induced byferroptosis in mice with Parkinson's disease | Ma X, Liu F, ..., Liu ZB | 10.13702/j.1000-0607.20221305 |
| 38364737 | Targeting iron-metabolism:a potential therapeutic strategy for pulmonaryfibrosis | Sun Y, Ren Y, ..., Yang ZS | 10.1016/j.biopha.2024.116270 |
| 38184712 | DMT1-dependent endosome-mitochondria interactions regulate mitochondrial irontranslocation and metastatic outgrowth | Barra J, Crosbourne I, ..., Barroso MM | 10.1038/s41388-023-02933-x |
| 38141840 | Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-inducedneuroinflammatory responses in a sex-specific manner | Volk Robertson K, Schleh MW, Harrison FE, Hasty AH | 10.1016/j.bbi.2023.12.020 |
| 38253961 | Oral iron therapy: Current concepts and future prospects for improving efficacyand outcomes | Ebea-Ugwuanyi PO, Vidyasagar S, ..., Collins JF | 10.1111/bjh.19268 |
| 38159178 | Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy viaTLR4/SLC7A11 Signaling Pathway | Lu JS, Wang JH, Han K, Li N | 10.1007/s10753-023-01954-8 |
| 38132482 | Hydrogen Attenuates Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy byRegulating Iron Metabolism | Song J, Chen Q, ..., Ji E | 10.3390/cimb45120636 |
| 38347764 | Gum Arabic-Derived Hydroxyproline-Rich Peptides Stimulate Intestinal Nonheme IronAbsorption via HIF2alpha-Dependent Upregulation of Iron Transport Proteins | Li S, Xing W, ..., Zhu S | 10.1021/acs.jafc.3c09588 |
| 38350216 | Zinc glycinate alleviates LPS-induced inflammation and intestinal barrierdisruption in chicken embryos by regulating zinc homeostasis and TLR4/NF-kappaBpathway | Xiao C, Comer L, ..., Song Z | 10.1016/j.ecoenv.2024.116111 |
| 38069795 | The Structural Basis for Metal Ion Transport in the SLC11/NRAMP Family | Manatschal C, Dutzler R | 10.2533/chimia.2022.1005 |
| 38292117 | Iron from the gut: the role of divalent metal transporter 1 | Okazaki Y | 10.3164/jcbn.23-47 |
| 38110647 | The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a PotentialTarget | Liu Y, Hu S, ..., Du X | 10.1007/s12035-023-03870-2 |
| 38331279 | Polystyrene microplastics mitigate lead-induced neurotoxicity by reducing heavymetal uptake in zebrafish larvae | Cao Q, Wei D, ..., Huang D | 10.1016/j.scitotenv.2024.170790 |
| 38243197 | Dysfunction of DMT1 and miR-135b in the gut-testis axis in high-fat diet malemice | Zhang Y, Ding R, ..., Liu E | 10.1186/s12263-024-00737-6 |
| 38134975 | The infection of Aeromonas hydrophila activated Multiple programmed cell deathpathways in red blood cells of Clarias fuscus | Tao J, Tu C, ..., Qin Z | 10.1016/j.fsi.2023.109315 |
| 38331112 | DMT1-mediated iron overload accelerates cartilage degeneration in HemophilicArthropathy through the mtDNA-cGAS-STING axis | Liu H, Chi R, ..., Guo F | 10.1016/j.bbadis.2024.167058 |
| 38069801 | Molecular Similarity for Drug Discovery, Target Prediction and Chemical SpaceVisualization | Reymond JL | 10.2533/chimia.2022.1045 |
| 38176318 | Developmental exposure to cobalt chloride affected mouse testis via altered ironmetabolism in adulthood | Pavlova E, Gluhcheva Y, ..., Atanassova N | 10.1016/j.jtemb.2023.127372 |
| 38366942 | Intracellular Regulation Limits the Response of Intestinal Ferroportin to IronStatus in Suckling Rats | Qiu L, Hu M, ..., Wang X | 10.1002/mnfr.202300617 |