Genomic location: Pf3D7_07_v3:1,265,910..1,281,347(+)
Miles Classification: Core
Product Description: dynein heavy chain, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005938 | cell cortex |
| Component | GO:0005868 | cytoplasmic dynein complex |
| Component | GO:0005881 | cytoplasmic microtubule |
| Component | GO:0030286 | dynein complex |
| Function | GO:0045505 | dynein intermediate chain binding |
| Function | GO:0051959 | dynein light intermediate chain binding |
| Function | GO:0008569 | minus-end-directed microtubule motor activity |
| Process | GO:0031122 | cytoplasmic microtubule organization |
| Process | GO:0051293 | establishment of spindle localization |
| Process | GO:0007018 | microtubule-based movement |
| Process | GO:0072382 | minus-end-directed vesicle transport along microtubule |
| Process | GO:0000278 | mitotic cell cycle |
| Process | GO:0007097 | nuclear migration |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0925400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100025
Most Similar Human Ortholog: Not available
All Human Orthologs (OrthoMCL):
| ENSG00000007174 | dynein axonemal heavy chain 9 |
| ENSG00000039139 | dynein axonemal heavy chain 5 |
| ENSG00000105877 | dynein axonemal heavy chain 11 |
| ENSG00000114841 | dynein axonemal heavy chain 1 |
| ENSG00000115423 | dynein axonemal heavy chain 6 |
| ENSG00000118997 | dynein axonemal heavy chain 7 |
| ENSG00000124721 | dynein axonemal heavy chain 8 |
| ENSG00000158486 | dynein axonemal heavy chain 3 |
| ENSG00000174844 | dynein axonemal heavy chain 12 |
| ENSG00000183914 | dynein axonemal heavy chain 2 |
| ENSG00000185842 | dynein axonemal heavy chain 14 |
| ENSG00000187240 | dynein cytoplasmic 2 heavy chain 1 |
| ENSG00000187775 | dynein axonemal heavy chain 17 |
| ENSG00000197102 | dynein cytoplasmic 1 heavy chain 1 |
| ENSG00000197653 | dynein axonemal heavy chain 10 |
| ENSG00000281935 | dynein axonemal heavy chain 10 |
Protein length: 5065 | Molecular Weight (kDa): 591.698
UniProt ID(s): A0A143ZY83
PDB ID(s): None
Isoelectric Point: 6.51
Protein Domain Annotations:
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR004273 | Dynein heavy chain region D6 P-loop domain |
| InterPro | IPR013594 | Dynein heavy chain, domain-1 |
| InterPro | IPR013602 | Dynein heavy chain, domain-2 |
| InterPro | IPR024317 | Dynein heavy chain, AAA module D4 |
| InterPro | IPR024743 | Dynein heavy chain, coiled coil stalk |
| InterPro | IPR026983 | Dynein heavy chain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR035699 | Dynein heavy chain, hydrolytic ATP-binding dynein motor region |
| InterPro | IPR035706 | Dynein heavy chain, ATP-binding dynein motor region |
| InterPro | IPR041228 | Dynein heavy chain, C-terminal domain |
| InterPro | IPR041466 | Dynein heavy chain, AAA 5 extension domain |
| InterPro | IPR041589 | Dynein heavy chain 3, AAA+ lid domain |
| InterPro | IPR041658 | Dynein heavy chain AAA lid domain |
| PFam | PF03028 | Dynein heavy chain region D6 P-loop domain |
| PFam | PF08385 | Dynein heavy chain, domain-1 |
| PFam | PF08393 | Dynein heavy chain, domain-2 |
| PFam | PF12774 | Dynein heavy chain, hydrolytic ATP-binding dynein motor region |
| PFam | PF12775 | Dynein heavy chain, coiled coil stalk |
| PFam | PF12777 | Dynein heavy chain, AAA module D4 |
| PFam | PF12780 | Dynein heavy chain, ATP-binding dynein motor region |
| PFam | PF12781 | Dynein heavy chain, AAA 5 extension domain |
| PFam | PF17852 | Dynein heavy chain 3, AAA+ lid domain |
| PFam | PF17857 | Dynein heavy chain AAA lid domain |
| PFam | PF18198 | Dynein heavy chain, C-terminal domain |
| PFam | PF18199 | |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
Old (Pf3D7v3) Gene ID: PF3D7_0729900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 40 | 229 | 117 | 251 |
| disruptive | 39 | 201 | 122 | 336 |
| missense | 33 | 190 | 115 | 300 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 78 | 466 | 184 | 227 |
| disruptive | 74 | 444 | 203 | 535 |
| missense | 56 | 389 | 185 | 391 |
PlasmoDB Total SNPs: 228
Non-coding: 13 | Synonymous: 150 | Nonsynonymous: 65 | Stop Codon: 0
No associated publications