Genomic location: Pf3D7_07_v3:1,324,452..1,333,940(+)
Miles Classification: Core
Product Description: EMP1-trafficking protein
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0043657 | host cell |
| Component | GO:0005634 | nucleus |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 2.65 | Trophozoite: 1.69 | Schizont: 0 | Gametocyte: 0
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBF2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 2110 | Molecular Weight (kDa): 244.195
UniProt ID(s): Q8IBF2
PDB ID(s): None
Isoelectric Point: 6.94
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0730900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 18 | 27 |
| disruptive | 21 | 51 | 35 | 103 |
| missense | 21 | 50 | 34 | 89 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 36 | 21 | 26 |
| disruptive | 35 | 126 | 79 | 143 |
| missense | 32 | 106 | 64 | 95 |
PlasmoDB Total SNPs: 495
Non-coding: 106 | Synonymous: 238 | Nonsynonymous: 150 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |
| 28426751 | The role of microsporidian polar tube protein 4 (PTP4) in host cell infection | Han B, Polonais V, ..., Weiss LM | 10.1371/journal.ppat.1006341 |
| 20413845 | Expression profile of tyrosine phosphatases in HER2 breast cancer cells andtumors | Lucci MA, Orlandi R, ..., Villa-Moruzzi E | 10.3233/CLO-2010-0520 |
| 30036623 | Chemical characterization and antioxidant activities of polysaccharides isolatedfrom the stems of Parthenocissus tricuspidata | Liang X, Gao Y, ..., Zhang W | 10.1016/j.ijbiomac.2018.07.131 |
| 15303168 | Ring-opening reactions induced by gold(I) of five- and four-coordinatepalladium(II) and platinum(II) complexes containing tripodal or linearpolyphosphines | Fernandez D, Garcia-Seijo MI, Castineiras A, Garcia-Fernandez ME | 10.1039/B406726F |
| 11955632 | A potential membrane protein involved in pre-tRNA splicing of Schizosaccharomycespombe | Kim M, Hwang K, Lim CJ, Kim D | 10.1016/s0167-4781(01)00353-0 |
| 36695178 | Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion inclosed mitosis | Foo S, Cazenave-Gassiot A, Wenk MR, Oliferenko S | 10.1242/jcs.260568 |
| 31431557 | Microsporidia Interact with Host Cell Mitochondria via Voltage-Dependent AnionChannels Using Sporoplasm Surface Protein 1 | Han B, Ma Y, ..., Weiss LM | 10.1128/mBio.01944-19 |
| 2468673 | Phosphotyrosyl-protein phosphatases. I. Separation of multiple forms from bovinebrain and purification of the major form to near homogeneity | Jones SW, Erikson RL, Ingebritsen VM, Ingebritsen TS | |
| 37253964 | Identification and localization of polar tube proteins in the extruded polar tubeof the microsporidian Anncaliia algerae | Fayet M, Prybylski N, ..., Delbac F | 10.1038/s41598-023-35511-y |
| 38214422 | Mesomorphism Modulation of Perfluorinated Janus Triphenylenes by InhomogeneousChain Substitution Patterns | Zhang KL, Yu WH, ..., Donnio B | 10.1002/asia.202301080 |
| 22118986 | Involvement of SHP2 in focal adhesion, migration and differentiation of neuralstem cells | Huang YS, Cheng CY, ..., Ma KH | 10.1016/j.braindev.2011.10.011 |
| 29722096 | The 14th International Workshops on Opportunistic Protists (IWOP 14) | Cushion MT, Limper AH, ..., Weiss LM | 10.1111/jeu.12631 |
| 19129592 | (Di-tert-butylmethylphosphane)(eta2-di-tert-butylphosphanylphosphinidene)(triphenylphosphane)platinum(0) | Konitz A, Krautscheid H, Pikies J | 10.1107/S0108270108037979 |
| 9861724 | Measurement and interpretation of Q0 and Q1 band property changes of two cationicmetalloporphyrins upon binding with B-DNA: electronic MCD, CD, and opticalabsorption | Barnes NR, Schreiner AF, Dolan MA | 10.1016/s0162-0134(98)10050-8 |
| 2468674 | Phosphotyrosyl-protein phosphatases. II. Identification and characterization oftwo heat-stable protein inhibitors | Ingebritsen TS |