Genomic location: Pf3D7_08_v3:794,136..798,695(-)
Miles Classification: Core
Product Description: phosphatase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003690 | double-stranded DNA binding |
| Function | GO:0046404 | polydeoxyribonucleotide 5'-hydroxyl-kinase activity |
| Function | GO:0046403 | polynucleotide 3'-phosphatase activity |
| Process | GO:0006281 | DNA repair |
| Process | GO:0046939 | nucleotide phosphorylation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0713400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4V3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 739 | Molecular Weight (kDa): 89.108
UniProt ID(s): C0H4V3
PDB ID(s): None
Isoelectric Point: 9.79
Protein Domain Annotations:
| InterPro | IPR013954 | Polynucleotide kinase 3 phosphatase |
| InterPro | IPR036412 | HAD-like superfamily |
| PFam | PF08645 | Polynucleotide kinase 3 phosphatase |
| Superfamily | SSF56784 | HAD-like superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_0817400
Resistome Missense Mutations: L402I
Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 18 | 37 |
| disruptive | 29 | 84 | 49 | 106 |
| missense | 19 | 63 | 41 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 52 | 20 | 49 |
| disruptive | 51 | 201 | 91 | 205 |
| missense | 28 | 137 | 72 | 105 |
PlasmoDB Total SNPs: 298
Non-coding: 175 | Synonymous: 54 | Nonsynonymous: 68 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 8944766 | Computational method to predict mitochondrially imported proteins and theirtargeting sequences. | Claros MG, Vincens P | 10.1111/j.1432-1033.1996.00779.x |