Genomic location: Pf3D7_09_v3:366,444..367,723(+)
Miles Classification: Core
Product Description: ribosomal protein L35, apicoplast, putative
SignalP Peptide: MKCLLVKLFMLIFIRSYTYA
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020011 | apicoplast |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0809200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I373
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 191 | Molecular Weight (kDa): 22.743
UniProt ID(s): Q8I373
PDB ID(s): None
Isoelectric Point: 11.28
Protein Domain Annotations:
| InterPro | IPR001706 | Ribosomal protein L35, non-mitochondrial |
| InterPro | IPR018265 | Ribosomal protein L35, conserved site |
| InterPro | IPR021137 | Ribosomal protein L35 |
| InterPro | IPR037229 | Ribosomal protein L35 superfamily |
| PFam | PF01632 | Ribosomal protein L35 |
| Superfamily | SSF143034 | Ribosomal protein L35 superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_0907800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 14 | 6 | 18 |
| disruptive | 4 | 22 | 19 | 38 |
| missense | 4 | 22 | 19 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 30 | 12 | 24 |
| disruptive | 12 | 52 | 28 | 45 |
| missense | 9 | 45 | 25 | 38 |
PlasmoDB Total SNPs: 123
Non-coding: 103 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |