Genomic location: Pf3D7_09_v3:646,547..649,563(-)
Miles Classification: Core
Product Description: heptatricopeptide repeat-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0816300)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2Z9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 721 | Molecular Weight (kDa): 85.408
UniProt ID(s): Q8I2Z9
PDB ID(s): None
Isoelectric Point: 9.35
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0915300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 47 | 30 | 65 |
| disruptive | 23 | 135 | 85 | 178 |
| missense | 15 | 121 | 75 | 159 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 92 | 48 | 69 |
| disruptive | 58 | 267 | 133 | 232 |
| missense | 42 | 226 | 117 | 171 |
PlasmoDB Total SNPs: 132
Non-coding: 74 | Synonymous: 30 | Nonsynonymous: 28 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30102371 | Identification of clustered organellar short (cos) RNAs and of a conserved familyof organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in themalaria parasite. | Hillebrand A, Matz JM, ..., Schmitz-Linneweber C | 10.1093/nar/gky710 |