Genomic location: Pf3D7_09_v3:712,444..715,666(-)
Miles Classification: Core
Product Description: N-glycosylase/DNA lyase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.2.2.- (Hydrolyzing N-glycosyl compounds.);4.2.99.18 (DNA-(apurinic or apyrimidinic site) lyase)
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0034039 | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| Process | GO:0006285 | base-excision repair, AP site formation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2Y2
"Best" AlphaFill ligand hit: NO3 (nitrate ion, Local RMSD=0.23) with 6W0R (Global RMSD=1.96)
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| O15527 | N-glycosylase/DNA lyase | OrthoDB | 3,4‐Dichloro‐1‐benzothiophene‐2‐carbohydrazide (08)3‐Chloro‐N'‐[(1Z)‐2‐methylcyclohexylidene]‐1‐benzothiophene‐2‐carbohydrazide (0154)3-Chloro‐N'‐[(1E)‐(4‐fluorophenyl)methylidene]‐1‐... |
Ortholog Group (OrthoMCL): OG6_102483
Most Similar Human Ortholog: O15527
All Human Orthologs (OrthoMCL):
| ENSG00000114026 | 8-oxoguanine DNA glycosylase |
Protein length: 757 | Molecular Weight (kDa): 89.361
PDB ID(s): None
Isoelectric Point: 10.09
Protein Domain Annotations:
| InterPro | IPR003265 | HhH-GPD domain |
| InterPro | IPR011257 | DNA glycosylase |
| InterPro | IPR012904 | 8-oxoguanine DNA glycosylase, N-terminal |
| PFam | PF00730 | HhH-GPD domain |
| PFam | PF07934 | 8-oxoguanine DNA glycosylase, N-terminal |
| Superfamily | SSF48150 | DNA glycosylase |
| Superfamily | SSF55945 |
Old (Pf3D7v3) Gene ID: PF3D7_0917100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 37 | 27 | 53 |
| disruptive | 32 | 125 | 88 | 177 |
| missense | 27 | 117 | 84 | 147 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 77 | 44 | 43 |
| disruptive | 63 | 283 | 133 | 214 |
| missense | 46 | 243 | 108 | 140 |
PlasmoDB Total SNPs: 152
Non-coding: 84 | Synonymous: 23 | Nonsynonymous: 45 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 8944766 | Computational method to predict mitochondrially imported proteins and theirtargeting sequences. | Claros MG, Vincens P | 10.1111/j.1432-1033.1996.00779.x |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38255794 | DNA Mutagenicity of Hydroxyhydroquinone in Roasted Coffee Products and ItsSuppression by Chlorogenic Acid, a Coffee Polyphenol, inOxidative-Damage-Sensitive SAMP8 Mice | Unno K, Taguchi K, ..., Nakamura Y | 10.3390/ijms25020720 |
| 38201575 | OGG1 as an Epigenetic Reader Affects NFkappaB: What This Means for Cancer | Vlahopoulos S, Pan L, ..., Boldogh I | 10.3390/cancers16010148 |
| 38282476 | 8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21pathway | Gao S, Chen L, ..., Liu G | 10.3724/abbs.2023264 |
| 38337103 | Aberrant Repair of 8-Oxoguanine in Short DNA Bulges | Eroshenko DA, Diatlova EA, ..., Zharkov DO | 10.1134/S1607672923600355 |
| 38101146 | Targeted nuclear irradiation with a proton microbeam induces oxidative DNA basedamage and triggers the recruitment of DNA glycosylases OGG1 and NTH1 | Robeska E, Lalanne K, ..., Baldeyron C | 10.1016/j.dnarep.2023.103610 |
| 38334141 | Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and riskof cardiovascular disease | Alomair A, Alamri A, ..., Alanazi M | 10.3892/mmr.2024.13177 |
| 38146704 | Human epithelial lung cell toxicity assessment of collected graphite particlesfrom an iron casting industry (in vitro study) | Zendehdel R, Hahad O, Panjali Z | 10.1080/09603123.2023.2298248 |
| 38368415 | Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LETprotons through complex DNA damage persistence | Fabbrizi MR, Nickson CM, ..., Parsons JL | 10.1038/s41419-024-06541-9 |
| 38236479 | Investigation of APE1 and OGG1 expression in chronic hemodialysis patients | Rostami M, Yalin SF, Altiparmak MR, Guven M | 10.1007/s11033-023-09152-3 |
| 38237481 | Single-molecule analysis of purified proteins and nuclear extracts: Insights from8-oxoguanine glycosylase 1 | Schaich MA, Weaver TM, ..., Van Houten B | 10.1016/j.dnarep.2024.103625 |
| 38363604 | OGG1 prevents atherosclerosis-induced vascular endothelial cell injury throughmediating DNA damage repair | Zhang YM, Wang GH, Xu MJ, Jin G | 10.3233/CH-232082 |
| 38344773 | The potential for OGG1 inhibition to be a therapeutic strategy for pulmonarydiseases | Pan L, Boldogh I | 10.1080/14728222.2024.2317900 |
| 38055144 | Functional Characterization of DNA N-Glycosylase Ogg1 and Ntg1 in DNA DamageStress of Cryptococcus neoformans | Jung KW, Kwon S, ..., Bahn YS | 10.1007/s12275-023-00092-y |
| 38397143 | Cognitive Function Is Associated with the Genetically Determined Efficiency ofDNA Repair Mechanisms | Cherbuin N, Patel H, ..., Rasmussen LJ | 10.3390/genes15020153 |
| 38028180 | Effect of IFN‑gamma encapsulated liposomes on major signal transduction pathways inthe lymphocytes of patients with lung cancer | Alhawamdeh M, Almajali B, ..., Tarawneh IA | 10.3892/ol.2023.14141 |
| 38381482 | Epistasis between mutator alleles contributes to germline mutation spectrumvariability in laboratory mice | Sasani TA, Quinlan AR, Harris K | 10.7554/eLife.89096 |
| 38018207 | Comprehensive Analyses and Experiments Confirmed IGFBP5 as a Prognostic PredictorBased on an Aging-genomic Landscape Analysis of Ovarian Cancer | Fan TY, Xu LL, ..., Li YK | 10.2174/0115680096276852231113111412 |
| 38228016 | Catalytic activity of OGG1 is impaired by Zinc deficiency | Sharma P, Wong CP, Ho E, Sampath H | 10.1016/j.dnarep.2024.103628 |
| 38065035 | Modulation of gene expression and influence of gene polymorphisms related togenotoxicity and redox status on occupational exposure to inhaled anesthetics | Silva MAP, Figueiredo DBS, ..., Braz MG | 10.1016/j.ijheh.2023.114307 |
| 38396961 | Analysis of the Model of Atherosclerosis Formation in Pig Hearts as a Result ofImpaired Activity of DNA Repair Enzymes | Paslawski R, Kowalczyk P, ..., Szuba A | 10.3390/ijms25042282 |