Genomic location: Pf3D7_09_v3:1,128,345..1,130,169(+)
Miles Classification: Core
Product Description: cytochrome c oxidase subunit 5B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
| Process | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
| Process | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS *tentative
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0828600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2N1
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Protein length: 273 | Molecular Weight (kDa): 32.364
UniProt ID(s): Q8I2N1
PDB ID(s): None
Isoelectric Point: 6.68
Protein Domain Annotations:
| InterPro | IPR002124 | Cytochrome c oxidase, subunit Vb |
| PFam | PF01215 | Cytochrome c oxidase, subunit Vb |
| Superfamily | SSF57802 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_0927800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 13 | 7 | 19 |
| disruptive | 0 | 3 | 3 | 23 |
| missense | 0 | 3 | 2 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 32 | 15 | 16 |
| disruptive | 2 | 11 | 19 | 64 |
| missense | 1 | 9 | 15 | 47 |
PlasmoDB Total SNPs: 121
Non-coding: 110 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35472435 | Regulation of gut microbiota and intestinal metabolites by Poria cocosoligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fedmice | Zhu L, Ye C, ..., Liu H | 10.1016/j.jnutbio.2022.109019 |
| 37494999 | Boar fertility is controlled through systematic changes of mitochondrial proteinexpression during sperm capacitation | Lee BM, Park YJ, ..., Pang MG | 10.1016/j.ijbiomac.2023.125955 |
| 38096616 | NDUFA8 is transcriptionally regulated by EP300/H3K27ac and promotes mitochondrialrespiration to support proliferation and inhibit apoptosis in cervical cancer | Xiang H, Tang H, ..., Wang Y | 10.1016/j.bbrc.2023.149374 |
| 36307669 | NDUFA4 promotes cell proliferation by enhancing oxidative phosphorylation inpancreatic adenocarcinoma | Zhang Y, Ge M, ..., Wu X | 10.1007/s10863-022-09949-0 |
| 36765499 | [Expression of Key Enzymes in Glucose Metabolism in Chronic Mountain Sickness andIts Correlation with Phenotype] | Gao YM, Han GX, ..., Xie YB | 10.19746/j.cnki.issn.1009-2137.2023.01.031 |
| 36551283 | Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils NovelPrognostic Biomarkers in Multiple Myeloma | Zhao J, Wang X, ..., He P | 10.3390/biom12121855 |
| 37510369 | Mutations in Structural Genes of the Mitochondrial Complex IV May InfluenceBreast Cancer | de Oliveira RC, Dos Reis SP, Cavalcante GC | 10.3390/genes14071465 |
| 36481571 | Graphene quantum dots disturbed the energy homeostasis by influencing lipidmetabolism of macrophages | Shao Y, Wang X, ..., Huang Y | 10.1016/j.tox.2022.153389 |
| 34439877 | GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in OvarianCancer | Ha JH, Jayaraman M, ..., Dhanasekaran DN | 10.3390/biom11081211 |
| 37256505 | Deoxynivalenol affects cell metabolism in vivo and inhibits protein synthesis inIPEC-1 cells | Nossol C, Landgraf P, ..., Rothkotter HJ | 10.1007/s12550-023-00489-z |
| 35052740 | COX5B-Mediated Bioenergetic Alterations Modulate Cell Growth and Anticancer DrugSusceptibility by Orchestrating Claudin-2 Expression in Colorectal Cancers | Chu YD, Lim SN, Yeh CT, Lin WR | 10.3390/biomedicines10010060 |
| 37531568 | Melatonin supplementation promotes muscle fiber hypertrophy and regulates lipidmetabolism of skeletal muscle in weaned piglets | Chen W, Tu Y, ..., Shan T | 10.1093/jas/skad256 |
| 34655901 | Interactome of human and SARS-CoV-2 proteins to identify human hub proteinsassociated with comorbidities | Ghosh N, Saha I, Sharma N | 10.1016/j.compbiomed.2021.104889 |
| 38315405 | Bioinformatics to analyze the differentially expressed genes in different degreesof Alzheimer's disease and their roles in progress of the disease | Niu Y, Zhang Y, ..., Weng Q | 10.1007/s13353-024-00827-6 |
| 36737645 | Different effects of pesticides on transcripts of the endocrine regulation andenergy metabolism in honeybee foragers from different colonies | Christen V | 10.1038/s41598-023-29257-w |
| 36038328 | [Functional characteristics of YAP-positive hepatocytes expression in an earlystage of NASH with transcriptome sequence analysis] | Zeng WL, Liang JE, Liu YX, Wang Y | 10.3760/cma.j.cn501113-20200702-00364 |
| 38321686 | Mancozeb induces nephrotoxicity by impairing the oxidative phosphorylationpathway: A transcriptome study | Zhang Y, Wen R, ..., Wang X | 10.1016/j.ecoenv.2022.114471 |
| 36506395 | Identification and validation of the mitochondrial function related hub genes byunsupervised machine learning and multi-omics analyses in lung adenocarcinoma | Jin X, Zhang H, ..., Zhan C | 10.1016/j.heliyon.2022.e11966 |
| 37939958 | Protein lysine acetylation played an important role in NH(3)-induced AEC2 damageand pulmonary fibrosis in piglets | Wang X, Zhang D, ..., Yu M | 10.1016/j.scitotenv.2023.168303 |
| 35821008 | Distinct proteomic profiles in prefrontal subareas of elderly major depressivedisorder and bipolar disorder patients | Qi YJ, Lu YR, ..., Bao AM | 10.1038/s41398-022-02040-7 |