PfTargetHuntHelper

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Component

GO:0005634

nucleus

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS *tentative

Mutagenesis Index Score (MIS): 0.151
Mutagenesis Fitness Score (MFS): -2.893
Number of insertions in CDS: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0829300)

Relative Growth Rate: 0.86 ± 0.19
Confidence: 4.70

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0829300)

Gene Modification: Disrupted
RMgmDB ID Link: RMgm-2435

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2M4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532491

No human ortholog(s)

Protein Information

Protein length: 154 | Molecular Weight (kDa): 18.457

UniProt ID(s): Q8I2M4

PDB ID(s): None

Isoelectric Point: 11.15

Protein Domain Annotations:

InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0928500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	0	5
disruptive	7	22	17	31
missense	2	16	14	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	7	3	11
disruptive	14	58	24	58
missense	5	35	19	40

PlasmoDB Total SNPs: 178

Non-coding: 167 | Synonymous: 1 | Nonsynonymous: 10 | Stop Codon: 0

Associated Publications

PMID	Title	Authors	DOI
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108