PF3D7_0930800

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: 4.1.1.39 (Ribulose-bisphosphate carboxylase)

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Mutable in CDS

• Mutagenesis Index Score (MIS): 1
• Mutagenesis Fitness Score (MFS): -1.444
• Number of insertions in CDS: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_198259

No human ortholog(s)

Protein Information

Protein length: 4568 | Molecular Weight (kDa): 546.159

UniProt ID(s): C0H577

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0930800

Resistome Missense Mutations: N1477S

Resistome Compounds with Missense Mutations: ELQ300

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 414

Non-coding: 104 | Synonymous: 159 | Nonsynonymous: 151 | Stop Codon: 0

Associated Publications