Genomic location: Pf3D7_10_v3:66,845..69,602(-)
Miles Classification: NA
Product Description: acyl-CoA binding protein, isoform 1, ACBP1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Function | GO:0000062 | fatty-acyl-CoA binding |
| Process | GO:0006631 | fatty acid metabolic process |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 1.81 | Trophozoite: 0 | Schizont: 0 | Gametocyte: 0
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZZ93
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 313 | Molecular Weight (kDa): 36.504
UniProt ID(s): Q8IK25
PDB ID(s): None
Isoelectric Point: 7.36
Protein Domain Annotations:
| InterPro | IPR000582 | Acyl-CoA-binding protein, ACBP |
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| InterPro | IPR035984 | Acyl-CoA binding protein superfamily |
| PFam | PF00887 | Acyl-CoA-binding protein, ACBP |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | SSF47027 | Acyl-CoA binding protein superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1001100.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 174
Non-coding: 61 | Synonymous: 36 | Nonsynonymous: 73 | Stop Codon: 4
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31811889 | Biocontrol activity and putative mechanism of Bacillus amyloliquefaciens (SF14and SP10), Alcaligenes faecalis ACBC1, and Pantoea agglomerans ACBP1 againstbrown rot disease of fruit | Lahlali R, Aksissou W, ..., Amiri S | 10.1016/j.micpath.2019.103914 |
| 31397636 | The ACBP1-RAP2.12 signalling hub: A new perspective on integrative signallingduring hypoxia in plants | Schmidt RR, van Dongen JT | 10.1080/15592324.2019.1651184 |
| 25284079 | Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response tohypoxia by modulating very-long-chain fatty acid metabolism | Xie LJ, Yu LJ, ..., Xiao S | 10.1111/tpj.12692 |
| 30555504 | Overexpression of Acyl-CoA-Binding Protein 1 (ChACBP1) FromSaline-Alkali-Tolerant Chlorella sp. Enhances Stress Tolerance in Arabidopsis | Qiao K, Wang M, Takano T, Liu S | 10.3389/fpls.2018.01772 |
| 20345632 | The Arabidopsis acbp1acbp2 double mutant lacking acyl-CoA-binding proteins ACBP1and ACBP2 is embryo lethal | Chen QF, Xiao S, ..., Chye ML | 10.1111/j.1469-8137.2010.03231.x |
| 23448237 | Arabidopsis acyl-CoA-binding protein ACBP1 participates in the regulation of seedgermination and seedling development | Du ZY, Chen MX, ..., Chye ML | 10.1111/tpj.12121 |
| 21539519 | Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipidmetabolism in Caenorhabditis elegans | Elle IC, Simonsen KT, ..., Faergeman NJ | 10.1042/BJ20102099 |
| 20404541 | Arabidopsis acyl-CoA-binding proteins ACBP1 and ACBP2 show different roles infreezing stress | Du ZY, Xiao S, Chen QF, Chye ML | 10.4161/psb.11503 |
| 34066136 | Anti-Inflammatory and Anti-Platelet Properties of Lipid Bioactives from AppleCider By-Products | Tsoupras A, Moran D, ..., Zabetakis I | 10.3390/molecules26102869 |
| 34308254 | Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obesesubjects | Li S, Joseph A, Martins I, Kroemer G | 10.15698/cst2021.07.252 |
| 26662549 | Plant Cytosolic Acyl-CoA-Binding Proteins | Ye ZW, Chye ML | 10.1007/s11745-015-4103-z |
| 29288621 | Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2to modulate gene expression of homeodomain-leucine zipper IV transcriptionfactors | Lung SC, Liao P, ..., Chye ML | 10.1111/nph.14965 |
| 21670223 | Overexpression of Arabidopsis ACBP3 enhances NPR1-dependent plant resistance toPseudomonas syringe pv tomato DC3000 | Xiao S, Chye ML | 10.1104/pp.111.176933 |
| 29428423 | New potential bacterial antagonists for the biocontrol of fire blight disease(Erwinia amylovora) in Morocco | Ait Bahadou S, Ouijja A, ..., Lahlali R | 10.1016/j.micpath.2018.02.011 |
| 28500265 | Acyl-CoA-Binding Protein ACBP1 Modulates Sterol Synthesis during Embryogenesis | Lung SC, Liao P, ..., Chye ML | 10.1104/pp.17.00412 |
| 24906022 | Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confersPb(II) accumulation in Brassica juncea roots | DU ZY, Chen MX, ..., Chye ML | 10.1111/pce.12382 |
| 20442372 | Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotesstarvation-induced and age-dependent leaf senescence | Xiao S, Gao W, ..., Chye ML | 10.1105/tpc.110.075333 |
| 30362657 | Synergistic roles of acyl-CoA binding protein (ACBP1) and sterol carrier protein2 (SCP2) in Toxoplasma lipid metabolism | Fu Y, Cui X, ..., Liu Q | 10.1111/cmi.12970 |
| 25053648 | Arabidopsis membrane-associated acyl-CoA-binding protein ACBP1 is involved instem cuticle formation | Xue Y, Xiao S, ..., Chye ML | 10.1093/jxb/eru304 |
| 31595698 | Polyunsaturated linolenoyl-CoA modulates ERF-VII-mediated hypoxia signaling inArabidopsis | Zhou Y, Tan WJ, ..., Xiao S | 10.1111/jipb.12875 |