Genomic location: Pf3D7_10_v3:357,345..358,463(+)
Miles Classification: Core
Product Description: zinc finger (CCCH type) protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
N/AExpression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1206800)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJV8
"Best" AlphaFill ligand hit: NO3 (nitrate ion, Local RMSD=0.61) with 4WIN (Global RMSD=33.10)
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 372 | Molecular Weight (kDa): 43.991
UniProt ID(s): Q8IJV8
PDB ID(s): None
Isoelectric Point: 6.88
Protein Domain Annotations:
| InterPro | IPR000571 | Zinc finger, CCCH-type |
| InterPro | IPR036855 | Zinc finger, CCCH-type superfamily |
| PFam | PF00642 | Zinc finger, CCCH-type |
| PFam | PF14608 | |
| Superfamily | SSF90229 | Zinc finger, CCCH-type superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1008600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 25 | 20 | 31 |
| disruptive | 9 | 67 | 38 | 83 |
| missense | 7 | 45 | 30 | 63 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 64 | 14 | 26 |
| disruptive | 36 | 134 | 61 | 168 |
| missense | 18 | 99 | 51 | 82 |
PlasmoDB Total SNPs: 45
Non-coding: 0 | Synonymous: 30 | Nonsynonymous: 15 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |