Genomic location: Pf3D7_10_v3:632,488..635,500(+)
Miles Classification: Core
Product Description: ribonucleoside-diphosphate reductase small chain, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.17.4.1 (Ribonucleoside-diphosphate reductase)
Curated GO (PlasmoDB):
| Component | GO:0005971 | ribonucleoside-diphosphate reductase complex |
| Function | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| Process | GO:0006260 | DNA replication |
| Process | GO:0009186 | deoxyribonucleoside diphosphate metabolic process |
| Process | GO:0009263 | deoxyribonucleotide biosynthetic process |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1214200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJN8
"Best" AlphaFill ligand hit: FEO (mu-oxo-diiron, Local RMSD=2.13) with 1W68 (Global RMSD=2.27)
BRENDA EC Inhibitors:
| 1.17.4.1 | ribonucleoside-diphosphate reductase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Protein length: 335 | Molecular Weight (kDa): 40.388
PDB ID(s): None
Isoelectric Point: 5.2
Protein Domain Annotations:
| InterPro | IPR000358 | Ribonucleotide reductase small subunit family |
| InterPro | IPR009078 | Ferritin-like superfamily |
| InterPro | IPR033909 | Ribonucleotide reductase small subunit |
| PFam | PF00268 | Ribonucleotide reductase small subunit family |
| Superfamily | SSF47240 | Ferritin-like superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1015800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 5 | 17 |
| disruptive | 3 | 9 | 7 | 16 |
| missense | 3 | 9 | 7 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 22 | 14 | 22 |
| disruptive | 6 | 25 | 22 | 44 |
| missense | 5 | 22 | 18 | 29 |
PlasmoDB Total SNPs: 145
Non-coding: 123 | Synonymous: 16 | Nonsynonymous: 6 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |