Genomic location: Pf3D7_10_v3:729,698..733,223(-)
Miles Classification: Core
Product Description: peptidase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: N/A
Curated GO (PlasmoDB):
N/AExpression by stage, third quartile (Malaria Cell Atlas):
Ring: 2.21 | Trophozoite: 1.58 | Schizont: 0 | Gametocyte: 1.43
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0502600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3D0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 1015 | Molecular Weight (kDa): 118.419
PDB ID(s): None
Isoelectric Point: 5.55
Protein Domain Annotations:
| InterPro | IPR021109 | Aspartic peptidase domain superfamily |
| InterPro | IPR039755 | TBC1 domain family member 23 |
| PFam | N/A | N/A |
| Superfamily | SSF50630 | Aspartic peptidase domain superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1018300
Resistome Missense Mutations: T570N
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 42 | 26 | 63 |
| disruptive | 32 | 105 | 59 | 181 |
| missense | 28 | 90 | 49 | 152 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 90 | 46 | 72 |
| disruptive | 53 | 279 | 121 | 293 |
| missense | 44 | 220 | 93 | 164 |
PlasmoDB Total SNPs: 171
Non-coding: 56 | Synonymous: 67 | Nonsynonymous: 48 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |