PF3D7_1019600

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Mutable in CDS

• Mutagenesis Index Score (MIS): 1
• Mutagenesis Fitness Score (MFS): -0.196
• Number of insertions in CDS: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0503800)

• Relative Growth Rate: 0.90 ± 0.12
• Confidence: 5.66

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0503800)

• Gene Modification: Disrupted
• RMgmDB ID Link: RMgm-1951

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJK6

"Best" AlphaFill ligand hit: PLP (vitamin b6 phosphate, Local RMSD=15.09) with 4DGT (Global RMSD=20.78)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533142

No human ortholog(s)

Protein Information

Protein length: 1210 | Molecular Weight (kDa): 145.834

UniProt ID(s): Q8IJK6

PDB ID(s): None

Isoelectric Point: 6.43

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1019600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 329

Non-coding: 74 | Synonymous: 153 | Nonsynonymous: 102 | Stop Codon: 0

Associated Publications