Genomic location: Pf3D7_10_v3:1,481,557..1,486,315(-)
Miles Classification: Core
Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Function | GO:0061630 | ubiquitin protein ligase activity |
| Process | GO:0006513 | protein monoubiquitination |
| Process | GO:0000209 | protein polyubiquitination |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ33
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 1196 | Molecular Weight (kDa): 145.148
UniProt ID(s): Q8IJ33
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1037400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 49 | 25 | 58 |
| disruptive | 46 | 192 | 82 | 199 |
| missense | 38 | 177 | 80 | 174 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 106 | 44 | 66 |
| disruptive | 105 | 394 | 139 | 305 |
| missense | 72 | 318 | 113 | 191 |
PlasmoDB Total SNPs: 194
Non-coding: 68 | Synonymous: 72 | Nonsynonymous: 54 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |