About Gene List Toggle Layout

PF3D7_1142200

Genomic location: Pf3D7_11_v3:1,692,791..1,694,345(-)

Miles Classification: Core

Function and Localization

Product Description: vacuolar protein sorting-associated protein IST1-like, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

N/A

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Mutable in CDS

Mutagenesis Index Score (MIS): 1
Mutagenesis Fitness Score (MFS): -1.695
Number of insertions in CDS: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102849

Most Similar Human Ortholog: H3BQ38

TM-align score: 0.83526
TM-align length: 37 / 272
TM-align RMSD: 1.28
TM-align sequence identity: 0.027

All Human Orthologs (OrthoMCL):

ENSG00000182149

IST1 factor associated with ESCRT-III

Protein Information

Protein length: 272 | Molecular Weight (kDa): 32.612

UniProt ID(s): Q8IHU3

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	12	24
disruptive	6	28	19	49
missense	5	26	19	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	29	11	26
disruptive	10	76	36	82
missense	7	61	27	48

PlasmoDB Total SNPs: 99

Non-coding: 89 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 1

Associated Publications

PMID	Title	Authors	DOI
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097