PfTargetHuntHelper

Function and Localization

Product Description: serine/threonine protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)

Curated GO (PlasmoDB):

N/A

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Mutable in CDS

Mutagenesis Index Score (MIS): 1
Mutagenesis Fitness Score (MFS): -2.278
Number of insertions in CDS: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0903800)

Relative Growth Rate: 0.14 ± 0.16
Confidence: 5.07

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR5

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.26) with 3BQR (Global RMSD=7.40)

BRENDA EC Inhibitors:

2.7.11.1

non-specific serine/threonine protein kinase

ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148535

No human ortholog(s)

Protein Information

Protein length: 2015 | Molecular Weight (kDa): 238.765

UniProt ID(s): Q8IHR5

PDB ID(s): None

Isoelectric Point: 6

Protein Domain Annotations:

InterPro	IPR000719	Protein kinase domain
InterPro	IPR011009	Protein kinase-like domain superfamily
InterPro	IPR017441	Protein kinase, ATP binding site
PFam	PF00069	Protein kinase domain
Superfamily	SSF56112	Protein kinase-like domain superfamily

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	165	69	173
disruptive	149	567	260	549
missense	83	404	196	425

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	55	317	111	168
disruptive	289	1007	367	588
missense	157	753	274	395

PlasmoDB Total SNPs: 626

Non-coding: 348 | Synonymous: 124 | Nonsynonymous: 154 | Stop Codon: 0

Associated Publications

PMID	Title	Authors	DOI
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104