PfTargetHuntHelper

Function and Localization

Product Description: SND2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: N/A

Curated GO (PlasmoDB):

Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0006624	vacuolar protein processing

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS *tentative

Mutagenesis Index Score (MIS): 0.144
Mutagenesis Fitness Score (MFS): -2.953
Number of insertions in CDS: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1428600)

Gene Modification: Other
RMgmDB ID Link: RMgm-440

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103372

Most Similar Human Ortholog: Q9BTX3

TM-align score: 0.67394
TM-align length: 131 / 151
TM-align RMSD: 2.99
TM-align sequence identity: 0.115

All Human Orthologs (OrthoMCL):

ENSG00000168701

transmembrane protein 208

Protein Information

Protein length: 151 | Molecular Weight (kDa): 18.11

UniProt ID(s): C6S3K5

PDB ID(s): None

Isoelectric Point: 9.84

Protein Domain Annotations:

InterPro	IPR008506	SRP-independent targeting protein 2/TMEM208
PFam	PF05620	SRP-independent targeting protein 2/TMEM208
Superfamily	N/A	N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1212600.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	4	12
disruptive	0	9	11	28
missense	0	9	11	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	8	14
disruptive	0	43	27	52
missense	0	28	18	33

PlasmoDB Total SNPs: 95

Non-coding: 76 | Synonymous: 16 | Nonsynonymous: 3 | Stop Codon: 0

Associated Publications

PMID	Title	Authors	DOI
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097