Genomic location: Pf3D7_12_v3:656,653..658,519(-)
Miles Classification: Core
Product Description: male development gene 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0044310 | osmiophilic body |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Component | GO:0005774 | vacuolar membrane |
| Process | GO:0035891 | exit from host cell |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1432200)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 221 | Molecular Weight (kDa): 25.757
UniProt ID(s): Q8I5P2
PDB ID(s): None
Isoelectric Point: 4.39
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1216500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 3 | 9 |
| disruptive | 8 | 11 | 13 | 27 |
| missense | 8 | 11 | 13 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 8 | 15 |
| disruptive | 9 | 30 | 25 | 51 |
| missense | 9 | 27 | 23 | 42 |
PlasmoDB Total SNPs: 132
Non-coding: 110 | Synonymous: 10 | Nonsynonymous: 11 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16275909 | Disruption of a Plasmodium falciparum gene linked to male sexual developmentcauses early arrest in gametocytogenesis. | Furuya T, Mu J, ..., Su XZ | |
| 17367781 | Plasmodium falciparum: mRNA co-expression and protein co-localisation of two geneproducts upregulated in early gametocytes. | Lanfrancotti A, Bertuccini L, Silvestrini F, Alano P | 10.1016/j.exppara.2007.01.021 |
| 19438517 | Egress of Plasmodium berghei gametes from their host erythrocyte is mediated bythe MDV-1/PEG3 protein. | Ponzi M, Siden-Kiamos I, ..., Alano P | 10.1111/j.1462-5822.2009.01331.x |
| 35016700 | First report of Serotype-1 Marek's disease virus (MDV-1) with oncogenic form inbackyard turkeys in Turkey: a molecular analysis study | Ongor H, Timurkaan N, ..., Cetinkaya B | 10.1186/s12917-021-03130-2 |
| 37590302 | The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibitmitochondrial fission | He J, Liu K, ..., Fu C | 10.1371/journal.pbio.3002247 |
| 34575725 | Priming of Plant Defenses against Ophiostoma novo-ulmi by Elm (Ulmus minor Mill.)Fungal Endophytes | Martinez-Arias C, Sobrino-Plata J, ..., Martin JA | 10.3390/jof7090687 |
| 37605844 | Molecular characterization and phylogenetic analysis of Marek's disease virus inchickens from Ogun State, Nigeria | Oluwayinka EB, Otesile EB, ..., Dunn JR | 10.1080/03079457.2023.2243838 |
| 36106908 | Molecular Characterization and Phylogenetic Analysis of Marek's Disease Virus inIran | Ghalyanchilangeroudi A, Hosseini H, ..., Morshed R | 10.1637/aviandiseases-D-22-00018 |
| 37252401 | A quadruplex real-time PCR assay combined with a conventional PCR for thedifferential detection of Marek's disease virus vaccines and field strains | Wu S, Ding T, ..., Qin A | 10.3389/fvets.2023.1161441 |
| 36146851 | A New Strategy for Efficient Screening and Identification of MonoclonalAntibodies against Oncogenic Avian Herpesvirus Utilizing CRISPR/Cas9-BasedGene-Editing Technology | Teng M, Zhou ZY, ..., Luo J | 10.3390/v14092045 |
| 36398666 | Molecular and pathological investigations of Marek's disease outbreaks invaccinated poultry farms in Plateau State, North Central-Nigeria | Adedeji A, Abdu P, Akanbi O, Luka P | 10.12834/VetIt.2442.15397.1 |
| 35144044 | Marek's disease virus serine/threonine kinase Us3 facilitates viral replicationby targeting IRF7 to block IFN-beta production | Du X, Zhou D, ..., Cheng Z | 10.1016/j.vetmic.2022.109364 |
| 34923248 | Quantitative profiling of Marek's Disease Virus in vaccinated layer chicken | Kumar KS, P S, ..., A T | 10.1016/j.vetmic.2021.109305 |
| 35838750 | Occurrence of Marek's Disease in Backyard Chicken Flocks in Vietnam | Viet Thu HT, Trang HN, ..., Hien ND | 10.1637/aviandiseases-D-22-00009 |
| 36617590 | Critical roles of non-coding RNAs in lifecycle and biology of Marek's diseaseherpesvirus | Teng M, Zhu ZJ, ..., Luo J | 10.1007/s11427-022-2258-4 |
| 35484378 | Phylogenetic analyses on Marek's disease virus circulating in Iranian backyardand commercial poultry indicate viruses of different origin | Abtin A, Molouki A, ..., Shoushtari A | 10.1007/s42770-022-00738-w |
| 36016273 | Pathogenicity and Pathotype Analysis of Henan Isolates of Marek's Disease VirusReveal Long-Term Circulation of Highly Virulent MDV Variant in China | Teng M, Zheng LP, ..., Luo J | 10.3390/v14081651 |
| 36315934 | Genetic characterization of Marek's disease virus in chickens in Thailand revealsa high genetic diversity of circulating strains | Wannaratana S, Tunterak W, ..., Thontiravong A | 10.1111/tbed.14748 |
| 35812862 | Rapid, Sensitive, and Species-Specific Detection of Conventional and RecombinantHerpesvirus of Turkeys Vaccines Using Loop-Mediated Isothermal AmplificationCoupled With a Lateral Flow Device Readout | Mescolini G, Baigent SJ, Catelli E, Nair VK | 10.3389/fvets.2022.873163 |
| 35107377 | Targeted Deletion of Glycoprotein B Gene by CRISPR/Cas9 Nuclease Inhibits Gallidherpesvirus Type 3 in Dually Infected Marek's Disease Virus-TransformedLymphoblastoid Cell Line MSB-1 | Zhang Y, Li W, ..., Yao Y | 10.1128/jvi.02027-21 |
| 37112797 | Efficient Cross-Screening and Characterization of Monoclonal Antibodies againstMarek's Disease Specific Meq Oncoprotein Using CRISPR/Cas9-Gene-Edited Viruses | Teng M, Liu JL, ..., Luo J | 10.3390/v15040817 |
| 37492994 | Comparative proteomics of vesicles essential for the egress of Plasmodiumfalciparum gametocytes from red blood cells | Sassmannshausen J, Bennink S, ..., Pradel G | 10.1111/mmi.15125 |
| 36890573 | Marek's disease in chicken farms from Northwest Ethiopia: gross pathology, virusisolation, and molecular characterization | Birhan M, Gelaye E, ..., Bitew M | 10.1186/s12985-023-02003-4 |