PF3D7_1223500

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas):

Ring: 1.51 | Trophozoite: 2.16 | Schizont: 1.84 | Gametocyte: 2.55

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Non - Mutable in CDS

• Mutagenesis Index Score (MIS): 0.142
• Mutagenesis Fitness Score (MFS): -2.828
• Number of insertions in CDS: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1438400)

• Gene Modification: Other
• RMgmDB ID Link: RMgm-420

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532769

No human ortholog(s)

Protein Information

Protein length: 4505 | Molecular Weight (kDa): 544.357

UniProt ID(s): A0A144A125

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1223500

Resistome Missense Mutations: E1617K, R3757K

Resistome Compounds with Missense Mutations: Harzianin, RP-8

Resistome # Samples with Disruptive Mutations: 4 (2 missense, 2 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 443

Non-coding: 53 | Synonymous: 228 | Nonsynonymous: 162 | Stop Codon: 0

Associated Publications