Genomic location: Pf3D7_12_v3:971,186..972,341(+)
Miles Classification: Core
Product Description: citrate/oxoglutarate carrier protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005371 | tricarboxylate secondary active transmembrane transporter activity |
| Process | GO:0015742 | alpha-ketoglutarate transport |
| Process | GO:0006843 | mitochondrial citrate transmembrane transport |
| Process | GO:0006842 | tricarboxylic acid transport |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1438700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1438700)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5H9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 308 | Molecular Weight (kDa): 34.887
UniProt ID(s): Q8I5H9
PDB ID(s): None
Isoelectric Point: 9.89
Protein Domain Annotations:
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1223800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 5 | 11 |
| disruptive | 4 | 14 | 6 | 33 |
| missense | 2 | 13 | 6 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 21 | 9 | 16 |
| disruptive | 8 | 42 | 33 | 94 |
| missense | 6 | 31 | 26 | 56 |
PlasmoDB Total SNPs: 40
Non-coding: 27 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 30737343 | Mitochondrial Citrate Transporters CtpA and YhmA Are Required for ExtracellularCitric Acid Accumulation and Contribute to Cytosolic Acetyl Coenzyme A Generationin Aspergillus luchuensis mut. kawachii | Kadooka C, Izumitsu K, ..., Futagami T | 10.1128/AEM.03136-18 |
| 27707801 | Mitochondrial Carriers Link the Catabolism of Hydroxyaromatic Compounds to theCentral Metabolism in Candida parapsilosis | Zeman I, Nebohacova M, ..., Nosek J | 10.1534/g3.116.034389 |
| 28784321 | Three mitochondrial transporters of Saccharomyces cerevisiae are essential forammonium fixation and lysine biosynthesis in synthetic minimal medium | Scarcia P, Palmieri L, ..., Rottensteiner H | 10.1016/j.ymgme.2017.07.004 |
| 20371607 | Identification and functional characterization of a novel mitochondrial carrierfor citrate and oxoglutarate in Saccharomyces cerevisiae | Castegna A, Scarcia P, ..., Palmieri F | 10.1074/jbc.M109.097188 |
| 34320205 | Utilization of ethanol for itaconic acid biosynthesis by engineered Saccharomycescerevisiae | Xu Y, Li Z | 10.1093/femsyr/foab043 |
| 38339147 | Ctp1 and Yhm2: Two Mitochondrial Citrate Transporters to Support MetabolicFlexibility of Saccharomyces cerevisiae | Assalve G, Lunetti P, Zara V, Ferramosca A | 10.3390/ijms25031870 |
| 9742088 | A novel DNA-binding protein bound to the mitochondrial inner membrane restoresthe null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae | Cho JH, Ha SJ, ..., Chae CB | 10.1128/MCB.18.10.5712 |