Genomic location: Pf3D7_12_v3:1,249,652..1,250,988(-)
Miles Classification: Core
Product Description: subpellicular microtubule protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020025 | subpellicular microtubule |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS *tentative
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5B7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 258 | Molecular Weight (kDa): 30.19
UniProt ID(s): Q8I5B7
PDB ID(s): None
Isoelectric Point: 9.64
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1230300
Resistome Missense Mutations: L3H
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 3 | 15 |
| disruptive | 1 | 13 | 8 | 29 |
| missense | 1 | 13 | 8 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 21 | 8 | 16 |
| disruptive | 3 | 35 | 24 | 46 |
| missense | 3 | 33 | 22 | 36 |
PlasmoDB Total SNPs: 54
Non-coding: 42 | Synonymous: 8 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22021240 | SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii. | Tran JQ, Li C, ..., Morrissette NS | 10.1128/EC.05161-11 |
| 30228941 | Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysisof primary blasts from patients with a broad range of AML subtypes in combinationwith natural killer cells | Braciak TA, Roskopf CC, ..., Oduncu FS | 10.1080/2162402X.2018.1472195 |
| 31835530 | Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded ProteinO-Mannosylation | Castells-Ballester J, Rinis N, ..., Strahl S | 10.3390/ijms20246220 |
| 29595956 | Quadruple H-Bonding Cross-Linked Supramolecular Polymeric Materials as Substratesfor Stretchable, Antitearing, and Self-Healable Thin Film Electrodes | Yan X, Liu Z, ..., Bao Z | 10.1021/jacs.8b01682 |
| 28968928 | Effects of Tianmagouteng particles on brain cognitive function in spontaneouslyhypertensive rats with hyperactivity of liver-yang: A [F-18] FDG micro-PETimaging study | Zhang XJ, Sun TC, ..., Liu J | 10.1016/j.biopha.2017.08.100 |
| 31016356 | Co-occurrence of functional modules derived from nicotine-degrading gene clustersconfers additive effects in Pseudomonas sp. JY-Q | Li J, Wang J, ..., Zhong W | 10.1007/s00253-019-09800-4 |
| 29545157 | Development of an indirect ELISA based on the recombinant Spm2 protein fordetection of tropical theileriosis | Tian Z, Du X, ..., Yin H | 10.1016/j.actatropica.2018.03.003 |
| 30100927 | F-CphI represents a new homing endonuclease family using the Endo VII catalyticmotif | Fang X, Jiang Y, Li K, Zeng Q | 10.1186/s13100-018-0132-5 |
| 38007111 | Suspended particulate matter <2.5 mum (SPM(2.5)) in shallow lakes: Sedimentationresistance and bioavailable phosphorus enrichment after sediment resuspension | Zhou Z, Yan R, ..., Yi Q | 10.1016/j.scitotenv.2023.168780 |
| 34755497 | Molecular Weight Tuning of Organic Semiconductors for Curved Organic-InorganicHybrid X-Ray Detectors | Nanayakkara MPA, Masteghin MG, ..., Silva SRP | 10.1002/advs.202101746 |
| 35762466 | Microporous surface containing flower-like molybdenum disulfide submicro-spheresof sulfonated polyimide with antibacterial effect and promoting bone regenerationand osteointegration | Kaewmanee R, Wang F, ..., Wei J | 10.1039/d2bm00622g |
| 33397698 | Additional Role of Nicotinic Acid Hydroxylase for the Transformation of3-Succinoyl-Pyridine by Pseudomonas sp. Strain JY-Q | Li J, Li S, ..., Zhong W | 10.1128/AEM.02740-20 |
| 28248366 | Scattering of electromagnetic waves from 3D multilayer random rough surfacesbased on the second-order small perturbation method: energy conservation,reflectivity, and emissivity | Sanamzadeh M, Tsang L, ..., Tan S | 10.1364/JOSAA.34.000395 |
| 32103370 | Population-Based Bone Strain During Physical Activity: A Novel MethodDemonstrated for the Human Femur | Ziaeipoor H, Taylor M, Martelli S | 10.1007/s10439-020-02483-3 |
| 37975837 | The Sensory Processing Measure - Second Edition: A Critical Review and Appraisal | Brown T, Almiento L, Yu ML, Bhopti A | 10.1080/07380577.2023.2280216 |
| 35329994 | Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: ADescriptive Study Using the Sensory Processing Measure-2 (SPM-2) | Narzisi A, Fabbri-Destro M, ..., Masi G | 10.3390/jcm11061668 |
| 33667832 | Evaluation of sporozoite and macroschizont antigen (Spm2) of Theileria annulatafor its diagnostic potential | Prabhakaran HS, Ghosh KK, ..., Kumar M | 10.1016/j.ttbdis.2021.101691 |
| 28852400 | Long-term acupuncture treatment has a multi-targeting regulation on multiplebrain regions in rats with Alzheimer's disease: a positron emission tomographystudy | Lu YJ, Cai XW, ..., Steiner GZ | 10.4103/1673-5374.211197 |
| 38240656 | First Report of Alternaria Leaf Spot Caused by Alternaria alternata on Ulmusparvifolia in Jiangsu, China | Lyu Y, Dong X, ..., Huang LB | 10.1094/PDIS-10-23-2038-PDN |
| 35747497 | Response: Commentary: Evaluating Sensory Integration/Sensory ProcessingTreatment: Issues and Analysis | Schoen SA, Schaaf RC, ..., Roley SS | 10.3389/fnint.2022.874320 |
| 34363174 | The effect of PM(2.5)-related hazards on biomarkers of bronchial epithelial cells(A549) inflammation in Karaj and Fardis cities | Rahmatinia T, Kermani M, ..., Fanaei F | 10.1007/s11356-021-15723-3 |