PfTargetHuntHelper

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Component

GO:0005929

cilium

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Mutable in CDS

Mutagenesis Index Score (MIS): 1
Mutagenesis Fitness Score (MFS): -1.516
Number of insertions in CDS: 12

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1446000)

Relative Growth Rate: 0.90 ± 0.18
Confidence: 4.79

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1446000)

Gene Modification: Disrupted
RMgmDB ID Link: RMgm-3979

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5A7

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=5.10) with 5OXF (Global RMSD=25.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103131

Most Similar Human Ortholog: A0A6Q8PGQ7

TM-align score: 0.70779
TM-align length: 146 / 952
TM-align RMSD: 1.92
TM-align sequence identity: 0.315

All Human Orthologs (OrthoMCL):

ENSG00000116198

centrosomal protein 104

Protein Information

Protein length: 952 | Molecular Weight (kDa): 112.851

UniProt ID(s): Q8I5A7

PDB ID(s): None

Isoelectric Point: 6.94

Protein Domain Annotations:

InterPro	IPR008979	Galactose-binding-like domain superfamily
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold
Superfamily	SSF49785	Galactose-binding-like domain superfamily

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1231300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	44	19	45
disruptive	12	83	47	121
missense	12	78	43	107

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	74	22	50
disruptive	36	164	91	161
missense	21	143	72	120

PlasmoDB Total SNPs: 80

Non-coding: 24 | Synonymous: 34 | Nonsynonymous: 22 | Stop Codon: 0

Associated Publications

PMID	Title	Authors	DOI
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097