Genomic location: Pf3D7_12_v3:1,791,156..1,793,341(+)
Miles Classification: Core
Product Description: queuine tRNA-ribosyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.4.2.29 (tRNA-guanine(34) transglycosylase)
Curated GO (PlasmoDB):
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008479 | queuine tRNA-ribosyltransferase activity |
| Process | GO:0002099 | tRNA wobble guanine modification |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0615100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I507
"Best" AlphaFill ligand hit: TEW (6-tungstotellurate(vi), Local RMSD=0.26) with 7OVS (Global RMSD=4.89)
BRENDA EC Inhibitors:
| 2.4.2.29 | tRNA-guanosine34 preQ1 transglycosylase | ethylacetimidate4-aminophthalimidedimethylsuberimidate4-aminophthalhydrazide3,5-diaminophthalimide2,3-Dihydroxybenzoic acid2-aminopteridin-4(3H)-one3,5-diaminophthalhydrazide2-aminoquinazolin-4(3H)-onebenzimidazole-5-carboxylate2-methylamino-lin-benzoguanine2,6-diaminoquinazolin-4(3H)-one... |
Orthology to BindingDB Entries:
| Q9BXR0 | Queuine tRNA-ribosyltransferase catalytic subunit 1 | Homo sapiens | OrthoDB | CHEMBL6993CHEMBL487739 |
Ortholog Group (OrthoMCL): OG6_100602
Most Similar Human Ortholog: Q9BXR0
All Human Orthologs (OrthoMCL):
| ENSG00000213339 | queuine tRNA-ribosyltransferase catalytic subunit 1 |
Protein length: 639 | Molecular Weight (kDa): 74.945
UniProt ID(s): Q8I507
PDB ID(s): None
Isoelectric Point: 10
Protein Domain Annotations:
| InterPro | IPR002616 | tRNA-guanine(15) transglycosylase-like |
| InterPro | IPR036511 | Queuine tRNA-ribosyltransferase-like |
| PFam | PF01702 | tRNA-guanine(15) transglycosylase-like |
| Superfamily | SSF51713 | Queuine tRNA-ribosyltransferase-like |
Old (Pf3D7v3) Gene ID: PF3D7_1242200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 30 | 18 | 53 |
| disruptive | 14 | 69 | 44 | 101 |
| missense | 14 | 61 | 36 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 74 | 38 | 45 |
| disruptive | 35 | 154 | 72 | 180 |
| missense | 27 | 123 | 52 | 117 |
PlasmoDB Total SNPs: 53
Non-coding: 9 | Synonymous: 20 | Nonsynonymous: 23 | Stop Codon: 1
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25869381 | Identification of Plasmodium falciparum apicoplast-targeted tRNA-guaninetransglycosylase and its potential inhibitors using comparative genomics,molecular modelling, docking and simulation studies. | Sawhney B, Chopra K, Misra R, Ranjan A | 10.1080/07391102.2015.1040074 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38003265 | Association of Germline Variation in Driver Genes with Breast Cancer Risk inChilean Population | Morales-Pison S, Tapia JC, ..., Jara L | 10.3390/ijms242216076 |
| 38290660 | Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancerpathogenesis: A spotlight on the contribution of the endosome-lysosome system | Tang J, Lam GT, ..., Logan JM | 10.1016/j.canlet.2024.216639 |
| 38035953 | Integration of wood-based components - Cellulose nanofibrils and tannic acid -into a poly(vinyl alcohol) matrix to improve functional properties | Osolnik U, Vek V, ..., Poljansek I | 10.1016/j.ijbiomac.2023.128495 |
| 38106014 | A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing inPatients with Cancer | Veney D, Wei L, ..., Stover DG | 10.1101/2023.12.05.23299443 |
| 38157089 | Assessment of salt and drought stress on the biochemical and molecularfunctioning of onion cultivars | Chaudhry UK, Ozturk ZN, Gokce AF | 10.1007/s11033-023-08923-2 |
| 37937332 | Penetrant shape effects on activated dynamics and selectivity in polymer meltsand networks based on self-consistent cooperative hopping theory | Mei B, Schweizer KS | 10.1039/d3sm01139a |
| 37940227 | Association of Loneliness With Change in Physical and Emotional Health of OlderAdults During the COVID-19 Shutdown | Liu J, Gou RY, ..., Inouye SK | 10.1016/j.jagp.2023.07.015 |
| 38034357 | CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain highexpression in human hematopoietic iPSC-derived lineages and primary cells | Vlassis A, Jensen TL, ..., Gill RT | 10.1016/j.isci.2023.108287 |
| 37962280 | CCR5 promoter polymorphisms associated with nonsmall cell lung cancer | Lu T, Shi Y, ..., Liu S | 10.1111/iji.12644 |
| 38324426 | Toward ground-truth optical coherence tomography via three-dimensionalunsupervised deep learning processing and data | Wu R, Zheng F, ..., Ni G | 10.1109/TMI.2024.3363416 |
| 38027126 | Association between GLO1 variants and gestational diabetes mellitussusceptibility in a Chinese population: a preliminary study | Zeng Q, Yang T, ..., Guo R | 10.3389/fendo.2023.1235581 |
| 37985000 | Reference intervals and biological variation in parameters of the thrombingeneration test in healthy individuals | Olga M, Yuliya Z, ..., Tatyana V | 10.1111/ijlh.14205 |
| 37932470 | Aotus nancymaae model predicts human immune response to the placental malariavaccine candidate VAR2CSA | Doritchamou J, Nielsen MA, ..., Duffy PE | 10.1038/s41684-023-01274-2 |
| 38181786 | Structural and functional insights into tRNA recognition by human tRNA guaninetransglycosylase | Sievers K, Neumann P, ..., Ficner R | 10.1016/j.str.2023.12.006 |
| 38297292 | Network pharmacology and experimental validation to study the potential mechanismof Tongguanteng injection in regulating apoptosis in osteosarcoma | Wei L, Meng J, ..., Han Y | 10.1186/s12906-024-04354-z |
| 38168370 | A high-fidelity CRISPR-Cas13 system improves abnormalities associated withC9ORF72-linked ALS/FTD | McCallister TX, Lim CKW, ..., Gaj T | 10.1101/2023.12.12.571328 |
| 38159323 | A novel GATA1 variant p.G229D causing the defect of procoagulant plateletformation | Ding B, Mao Y, ..., Wang X | 10.1016/j.thromres.2023.12.015 |
| 38269296 | Efficient and heritable A-to-K base editing in rice and tomato | Li X, Xie J, ..., Tian Y | 10.1093/hr/uhad250 |
| 38106016 | Queuosine Salvage in Bartonella henselae Houston 1: A Unique Evolutionary Path | Quaiyum S, Yuan Y, ..., de Crecy-Lagard V | 10.1101/2023.12.05.570228 |
| 38251388 | Coinfection of Babesia and Borrelia in the Tick Ixodes ricinus-A Neglected Public Health Issue in Europe? | Jaenson TGT, Gray JS, Lindgren PE, Wilhelmsson P | 10.3390/pathogens13010081 |