Genomic location: Pf3D7_13_v3:57,109..58,422(-)
Miles Classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: MKVHYINILLFALPLNILVYN
# Transmembrane Domains: 1
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
| Process | GO:0020033 | antigenic variation |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEU5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 369 | Molecular Weight (kDa): 41.391
PDB ID(s): None
Isoelectric Point: 8.5
Protein Domain Annotations:
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1300700
Resistome Missense Mutations: G246R
Resistome Compounds with Missense Mutations: MMV1081413, OSM-S-106
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 680
Non-coding: 80 | Synonymous: 155 | Nonsynonymous: 437 | Stop Codon: 8
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
| 25751816 | RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. | Goel S, Palmkvist M, ..., Wahlgren M | 10.1038/nm.3812 |
| 33790470 | Structural basis of malaria RIFIN binding by LILRB1-containing antibodies. | Chen Y, Xu K, ..., Lanzavecchia A | 10.1038/s41586-021-03378-6 |