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PF3D7_1304300

Genomic location: Pf3D7_13_v3:230,753..231,760(+)

Miles Classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Component GO:0020011 apicoplast

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IES2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532944

No human ortholog(s)

Protein Information

Protein length: 213 | Molecular Weight (kDa): 25.736

UniProt ID(s): Q8IES2

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1304300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 17 6 14
disruptive 6 22 16 31
missense 5 16 12 28

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 26 6 12
disruptive 11 51 24 44
missense 8 36 17 28

PlasmoDB Total SNPs: 36

Non-coding: 14 | Synonymous: 11 | Nonsynonymous: 11 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895