Genomic location: Pf3D7_13_v3:519,563..520,735(-)
Miles Classification: Core
Product Description: ribosomal protein S35, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0005739 | mitochondrion |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEJ8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 280 | Molecular Weight (kDa): 33.797
UniProt ID(s): Q8IEJ8
PDB ID(s): None
Isoelectric Point: 10.36
Protein Domain Annotations:
| InterPro | IPR019349 | Ribosomal protein S24/S35, mitochondrial, conserved domain |
| PFam | PF10213 | Ribosomal protein S24/S35, mitochondrial, conserved domain |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1312300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 9 | 24 |
| disruptive | 3 | 31 | 14 | 50 |
| missense | 3 | 31 | 13 | 45 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 36 | 15 | 25 |
| disruptive | 8 | 63 | 38 | 61 |
| missense | 6 | 54 | 35 | 50 |
PlasmoDB Total SNPs: 16
Non-coding: 8 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 31339607 | Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. | Lacombe A, Maclean AE, ..., Sheiner L | 10.1111/mmi.14357 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |