Genomic location: Pf3D7_13_v3:1,142,949..1,144,084(+)
Miles Classification: Core
Product Description: ribonuclease P protein subunit RPR2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.26.5 (Ribonuclease P)
Curated GO (PlasmoDB):
| Component | GO:0005655 | nucleolar ribonuclease P complex |
| Component | GO:0030677 | ribonuclease P complex |
| Function | GO:0004526 | ribonuclease P activity |
| Process | GO:0008033 | tRNA processing |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1342400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE34
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 3.1.26.5 | ribonuclease P | ATPRNAEDTANH4+tRNASO42-NeoR5NeoG6NeoK6retinolneaminemat-tRNA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103265
Most Similar Human Ortholog: Q9H633
All Human Orthologs (OrthoMCL):
| ENSG00000241370 | ribonuclease P/MRP subunit p21 |
Protein length: 252 | Molecular Weight (kDa): 29.94
UniProt ID(s): Q8IE34
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| InterPro | IPR007175 | RNAse P, Rpr2/Rpp21 subunit |
| PFam | PF04032 | RNAse P, Rpr2/Rpp21 subunit |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1327200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 5 | 13 |
| disruptive | 8 | 33 | 18 | 46 |
| missense | 6 | 33 | 17 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 9 | 15 |
| disruptive | 15 | 78 | 31 | 51 |
| missense | 11 | 72 | 26 | 38 |
PlasmoDB Total SNPs: 48
Non-coding: 26 | Synonymous: 9 | Nonsynonymous: 13 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 11069016 | Subacute effects of a phosphorothionate pesticide on mixed function oxidases ofWistar rats | Mahboob M, Siddiqui MK, Jamil K | 10.1080/03601230009373305 |
| 2267665 | Hepatic and extra hepatic glutathione depletion and glutathione-S-transferaseinhibition by monocrotophos and its two thiol analogues | Siddiqui MK, Mahboob M, Mustafa M | 10.1016/0300-483x(90)90120-6 |
| 25273134 | Enhancement of RNA annealing and strand displacement found in archaealribonuclease P proteins is conserved in Escherichia coli protein C5 and yeastprotein Rpr2 | Furutani T, Hazeyama K, ..., Kimura M | 10.1080/09168451.2014.925780 |
| 15637077 | Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals anew unique protein component | Salinas K, Wierzbicki S, Zhou L, Schmitt ME | 10.1074/jbc.M409568200 |
| 37074161 | Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNaseP | Perederina A, Berezin I, Krasilnikov AS | 10.1080/15476286.2023.2201110 |
| 14550630 | The enigma of ribonuclease P evolution | Hartmann E, Hartmann RK | 10.1016/j.tig.2003.08.007 |
| 37923979 | Ampelopsis grossedentata Represents a New Host of the 16SrI Group of PhytoplasmaAssociated with Yellow Leaf Symptoms in China | Cao L, Deng W, ..., Cheng Y | 10.1094/PDIS-09-23-1820-PDN |
| 27142847 | Molecular and genetic characterization of barley mutants and genetic mapping ofmutant rpr2 required for Rpg1-mediated resistance against stem rust | Gill U, Brueggeman R, ..., Kleinhofs A | 10.1007/s00122-016-2721-3 |