Genomic location: Pf3D7_13_v3:1,154,684..1,158,545(+)
Miles Classification: Core
Product Description: conserved protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
Component | GO:0005829 | cytosol |
Component | GO:0005634 | nucleus |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K9F0
"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=2.62) with 6J0P (Global RMSD=28.30)
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 861 | Molecular Weight (kDa): 103.094
UniProt ID(s): A0A5K1K9F0
PDB ID(s): None
Isoelectric Point: 9.66
Protein Domain Annotations:
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1327500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 26 | 22 | 24 |
disruptive | 21 | 59 | 38 | 102 |
missense | 21 | 57 | 37 | 90 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 18 | 43 | 25 | 42 |
disruptive | 39 | 148 | 74 | 180 |
missense | 32 | 116 | 63 | 119 |
PlasmoDB Total SNPs: 220
Non-coding: 165 | Synonymous: 35 | Nonsynonymous: 20 | Stop Codon: 0
PMID | Title | Authors | DOI |
---|---|---|---|
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
24841368 | Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. | Butler CL, Lucas O, ..., White M | 10.1371/journal.pone.0097625 |