Genomic location: Pf3D7_13_v3:1,165,307..1,166,558(+)
Miles Classification: Core
Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.25.1 (Proteasome endopeptidase complex)
Curated GO (PlasmoDB):
N/AExpression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZX69
"Best" AlphaFill ligand hit: HEM (protoporphyrin ix containing fe, Local RMSD=3.42) with 6UNM (Global RMSD=19.39)
BRENDA EC Inhibitors:
| 3.4.25.1 | proteasome endopeptidase complex | ATPSDSPSIEDTANH4+EGTATLCKALLNNMDANLVSPI 1PA28... |
No evidence of orthology to BindingDB entries
Protein length: 138 | Molecular Weight (kDa): 16.759
UniProt ID(s): A0A143ZX69
PDB ID(s): None
Isoelectric Point: 4.69
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1327900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 2 | 4 |
| disruptive | 4 | 13 | 9 | 25 |
| missense | 3 | 12 | 7 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 9 | 5 | 8 |
| disruptive | 8 | 27 | 15 | 26 |
| missense | 5 | 26 | 9 | 23 |
PlasmoDB Total SNPs: 25
Non-coding: 20 | Synonymous: 1 | Nonsynonymous: 4 | Stop Codon: 0
No associated publications