PfTargetHuntHelper

Function and Localization

Product Description: ER lumen protein retaining receptor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: N/A

Curated GO (PlasmoDB):

Component	GO:0005794	Golgi apparatus
Component	GO:0005801	cis-Golgi network
Component	GO:0005783	endoplasmic reticulum
Function	GO:0046923	ER retention sequence binding
Function	GO:0045015	HDEL sequence binding
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006621	protein retention in ER lumen

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Zhang Phenotype: Non - Mutable in CDS

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1345400)

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

AlphaFill Uniprot ID: Q8IE22

"Best" AlphaFill ligand hit: CO2 (carbon dioxide, Local RMSD=0.07) with 7OYE (Global RMSD=4.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Ortholog Group (OrthoMCL): OG6_108960

No human ortholog(s)

Protein length: 284 | Molecular Weight (kDa): 32.806

UniProt ID(s): Q8IE22

PDB ID(s): None

Isoelectric Point: 7.28

Protein Domain Annotations:

InterPro	IPR000133	ER lumen protein retaining receptor
PFam	PF00810	ER lumen protein retaining receptor
Superfamily	N/A	N/A

Old (Pf3D7v3) Gene ID: PF3D7_1330400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	3	23
disruptive	0	3	3	9
missense	0	3	2	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	33	9	22
disruptive	0	20	16	59
missense	0	13	10	31

PlasmoDB Total SNPs: 151

Non-coding: 141 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0

No associated publications