Genomic location: Pf3D7_13_v3:1,340,768..1,341,856(+)
Miles Classification: Core
Product Description: SAM-dependent RNA methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.- (Methyltransferases.);2.1.1.220 (tRNA (adenine(58)-N(1))-methyltransferase)
Curated GO (PlasmoDB):
| Function | GO:0035241 | protein-arginine omega-N monomethyltransferase activity |
| Process | GO:0018216 | peptidyl-arginine methylation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE03
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=0.66) with 5H5F (Global RMSD=3.84)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Protein length: 218 | Molecular Weight (kDa): 25.489
UniProt ID(s): Q8IE03
PDB ID(s): None
Isoelectric Point: 4.46
Protein Domain Annotations:
| InterPro | IPR007364 | RNA methyltransferase TK0422/Sfm1 |
| PFam | PF04252 | RNA methyltransferase TK0422/Sfm1 |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1332500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 8 | 15 |
| disruptive | 1 | 9 | 2 | 14 |
| missense | 1 | 9 | 2 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 25 | 11 | 17 |
| disruptive | 2 | 17 | 11 | 29 |
| missense | 2 | 16 | 9 | 21 |
PlasmoDB Total SNPs: 85
Non-coding: 79 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
No associated publications