About Gene List Toggle Layout

PF3D7_1347600

Genomic location: Pf3D7_13_v3:1,902,723..1,905,355(+)

Miles Classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: N/A

Curated GO (PlasmoDB):

N/A

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Mutable in CDS

Mutagenesis Index Score (MIS): 1
Mutagenesis Fitness Score (MFS): -0.694
Number of insertions in CDS: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1360400)

Relative Growth Rate: 1.07 ± 0.15
Confidence: 5.14

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1366100)

Gene Modification: Disrupted
RMgmDB ID Link: RMgm-4793

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171856

No human ortholog(s)

Protein Information

Protein length: 277 | Molecular Weight (kDa): 32.377

UniProt ID(s): C0H5H7

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	9	21
disruptive	1	32	19	46
missense	1	31	19	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	26	11	20
disruptive	10	84	45	87
missense	5	65	39	56

PlasmoDB Total SNPs: 145

Non-coding: 138 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Associated Publications

No associated publications