Genomic location: Pf3D7_13_v3:2,350,110..2,353,226(-)
Miles Classification: Core
Product Description: high mobility group protein B4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0000785 | chromatin |
| Component | GO:0005634 | nucleus |
| Function | GO:0003697 | single-stranded DNA binding |
| Process | GO:0006268 | DNA unwinding involved in DNA replication |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1135500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1135500)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDB5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 252 | Molecular Weight (kDa): 29.916
UniProt ID(s): Q8IDB5
PDB ID(s): None
Isoelectric Point: 8.28
Protein Domain Annotations:
| InterPro | IPR003958 | Transcription factor CBF/NF-Y/archaeal histone domain |
| InterPro | IPR009071 | High mobility group box domain |
| InterPro | IPR009072 | Histone-fold |
| InterPro | IPR036910 | High mobility group box domain superfamily |
| PFam | PF00808 | Transcription factor CBF/NF-Y/archaeal histone domain |
| PFam | PF09011 | High mobility group box domain |
| Superfamily | SSF47095 | High mobility group box domain superfamily |
| Superfamily | SSF47113 | Histone-fold |
Old (Pf3D7v3) Gene ID: PF3D7_1359200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 10 | 17 |
| disruptive | 3 | 13 | 15 | 28 |
| missense | 3 | 13 | 15 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 29 | 16 | 15 |
| disruptive | 6 | 47 | 23 | 53 |
| missense | 4 | 37 | 19 | 39 |
PlasmoDB Total SNPs: 180
Non-coding: 175 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 27608812 | HMGB4 is expressed by neuronal cells and affects the expression of genes involvedin neural differentiation | Rouhiainen A, Zhao X, ..., Rauvala H | 10.1038/srep32960 |
| 35753437 | HMGB3 inhibition by miR-142-3p/sh-RNA modulates autophagy and induces apoptosisvia ROS accumulation and mitochondrial dysfunction and reduces the tumorigenicpotential of human breast cancer cells | Sharma P, Yadav P, ..., Karunagaran D | 10.1016/j.lfs.2022.120727 |
| 15110790 | Ectopic expression of the maize chromosomal HMGB1 protein causes defects in rootdevelopment of tobacco seedlings | Lichota J, Ritt C, Grasser KD | 10.1016/j.bbrc.2004.03.193 |
| 23303677 | Cryopreserved bovine spermatozoal transcript profile as revealed byhigh-throughput ribonucleic acid sequencing | Card CJ, Anderson EJ, ..., Sartini BL | 10.1095/biolreprod.112.103788 |
| 22901013 | Binding interaction of HMGB4 with cisplatin-modified DNA | Park S, Lippard SJ | 10.1021/bi300649v |
| 33069132 | RNA-Seq analysis reveals functionally relevant coding and non-coding RNAs incrossbred bull spermatozoa | Prakash MA, Kumaresan A, ..., Morrell JM | 10.1016/j.anireprosci.2020.106621 |
| 28096358 | Repair shielding of platinum-DNA lesions in testicular germ cell tumors byhigh-mobility group box protein 4 imparts cisplatin hypersensitivity | Awuah SG, Riddell IA, Lippard SJ | 10.1073/pnas.1615327114 |
| 25649181 | Identifying genetic loci associated with antidepressant drug response withdrug-gene interaction models in a population-based study | Noordam R, Direk N, ..., Visser LE | 10.1016/j.jpsychires.2015.01.005 |
| 17169924 | Characterization of transgenic Arabidopsis plants overexpressing high mobilitygroup B proteins under high salinity, drought or cold stress | Kwak KJ, Kim JY, Kim YO, Kang H | 10.1093/pcp/pcl057 |
| 22655796 | High-mobility group boxes mediate cell proliferation and radiosensitivity viaretinoblastoma-interaction-dependent and -independent mechanisms | Wang LL, Meng QH, ..., Fan SJ | 10.1089/cbr.2012.1199 |
| 20123072 | HMGB proteins: interactions with DNA and chromatin | Stros M | 10.1016/j.bbagrm.2009.09.008 |
| 25609838 | Combining RNA and protein profiling data with network interactions identifiesgenes associated with spermatogenesis in mouse and human | Petit FG, Kervarrec C, ..., Primig M | 10.1095/biolreprod.114.126250 |
| 36446526 | Transcriptome analyses in infertile men reveal germ cell-specific expression andsplicing patterns | Siebert-Kuss LM, Krenz H, ..., Laurentino S | 10.26508/lsa.202201633 |
| 36105089 | An integrative analysis of DNA methylation and gene expression to predict lungadenocarcinoma prognosis | Xu L, Huang Z, ..., Xie C | 10.3389/fgene.2022.970507 |
| 33428061 | The role of high mobility group protein B3 (HMGB3) in tumor proliferation anddrug resistance | Wen B, Wei YT, Zhao K | 10.1007/s11010-020-04015-y |
| 35207567 | Omics and Male Infertility: Highlighting the Application of Transcriptomic Data | Omolaoye TS, Omolaoye VA, ..., Du Plessis SS | 10.3390/life12020280 |
| 18987332 | HMGB4, a novel member of the HMGB family, is preferentially expressed in themouse testis and localizes to the basal pole of elongating spermatids | Catena R, Escoffier E, ..., Davidson I | 10.1095/biolreprod.108.070243 |
| 15209498 | Interactions of the basic N-terminal and the acidic C-terminal domains of themaize chromosomal HMGB1 protein | Thomsen MS, Franssen L, ..., Grasser KD | 10.1021/bi0499009 |
| 20940346 | Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3and HMGB4 proteins | Pedersen DS, Merkle T, ..., Grasser KD | 10.1104/pp.110.163055 |
| 30616326 | [Clinical application of high mobility group box nuclear protein 1 subcomponentin the progression of liver cancer] | Dong ZZ, Yao M, Zheng WJ, Yao DF | 10.3760/cma.j.issn.1007-3418.2018.11.014 |