Genomic location: Pf3D7_13_v3:2,668,028..2,671,369(-)
Miles Classification: Core
Product Description: phosphatidylserine synthase
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: 2.7.8.8 (CDP-diacylglycerol--serine O-phosphatidyltransferase)
Curated GO (PlasmoDB):
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups |
| Function | GO:0005515 | protein binding |
| Process | GO:0006659 | phosphatidylserine biosynthetic process |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5K9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 2.7.8.8 | CDP-diacylglycerol-serine O-phosphatidyltransferase | Triton X-100 |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101724
Most Similar Human Ortholog: Q9BVG9
All Human Orthologs (OrthoMCL):
| ENSG00000156471 | phosphatidylserine synthase 1 |
| ENSG00000174915 | phosphatidylserine synthase 2 |
| ENSG00000282367 | phosphatidylserine synthase 2 |
Protein length: 357 | Molecular Weight (kDa): 41.979
UniProt ID(s): C0H5K9
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| InterPro | IPR004277 | Phosphatidyl serine synthase |
| PFam | PF03034 | Phosphatidyl serine synthase |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1366800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 24 | 13 | 22 |
| disruptive | 20 | 24 | 17 | 29 |
| missense | 20 | 24 | 17 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 47 | 14 | 28 |
| disruptive | 23 | 54 | 36 | 75 |
| missense | 23 | 49 | 34 | 54 |
PlasmoDB Total SNPs: 262
Non-coding: 231 | Synonymous: 9 | Nonsynonymous: 22 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 35623558 | Defining ER-mitochondria contact dynamics in Plasmodium falciparum by targetingcomponent of phospholipid synthesis pathway, phosphatidylserine synthase (PfPSS). | Anwar MO, Islam MM, ..., Mohmmed A | 10.1016/j.mito.2022.05.005 |
| 38428428 | Therapeutic benefit of idebenone in patients with Leber hereditary opticneuropathy: The LEROS nonrandomized controlled trial | Yu-Wai-Man P, Carelli V, ..., Klopstock T | 10.1016/j.xcrm.2024.101437 |
| 38410309 | Cranial Neuropathy As Initial Manifestation of Primary Sjogren's Syndrome: A CaseSeries With Literature Review | Lagtarna H, Naji Y, Adali N | 10.7759/cureus.53063 |
| 38426646 | Cognitively Driven Autonomous Flow Chemistry for Producing On-Demand PerovskiteQuantum Dots Via Advanced Closed-Loop Feedback Control | Nguyen TTH, Bui HK, Im JY, Seo TS | 10.1002/smtd.202400094 |
| 38427565 | Integration of in vivo electrophysiology and optogenetics in rodents withPEDOT:PSS neural electrode array | Cho YU, Lee JY, Yu KJ | 10.1016/j.xpro.2024.102909 |
| 38428700 | Primary Arthroscopic Repair for Massive Rotator Cuff Tears Results in GoodShoulder Function, Low Pain, and Satisfactory Outcomes at 2-Year MinimumFollow-Up | Rosenblum J, Madi R, ..., Kelly JD 4th | 10.1016/j.arthro.2024.02.026 |
| 38406824 | Implications of IFNgamma SNP rs2069705 in Primary Sjogren's Syndrome: TranscriptionalActivation and B Cell Infiltration | Chen X, Li M, ..., Ji Y | 10.1152/ajpcell.00661.2023 |
| 38423422 | Surfactant-assisted preparation of all-gel-state flexible supercapacitor withremarkable electrochemical performance based on polyaniline-polyacrylamide/sodiumalginate hydrogels | Song C, Yu L, ..., Li M | 10.1016/j.ijbiomac.2024.130449 |
| 38416419 | Schottky Barrier-Based Built-In Electric Field for Enhanced Tumor PhotodynamicTherapy | Sun Y, Wang H, ..., Liu H | 10.1021/acsami.4c00018 |
| 38418533 | Relationship among post-traumatic growth, spiritual well-being, and perceivedsocial support in Chinese women with gynecological cancer | Feng Y, Liu X, ..., Chen J | 10.1038/s41598-024-55605-5 |
| 38429688 | Contextualizing medications for opioid use disorder and peer support serviceprovision in the probation system with implementation science | Kang AW, Bailey A, Napoleon S, Martin R | 10.1186/s12889-024-18133-5 |
| 38423544 | Influencing factors on the psychosomatic health of medical staff since thenormalized stage of COVID-19 in mainland China | Jiao XA, Bai RA, Li N, Liu K | 10.1093/eurpub/ckae021 |
| 38421078 | Polymeric Conductive Adhesive based Ultrathin Epidermal Electrodes for Long-termMonitoring of Electrophysiological Signals | Shin JH, Choi JY, ..., Kim TI | 10.1002/adma.202313157 |
| 38409708 | Recent Advances in Chemistry, Mechanism, and Applications of Quantum Dots inPhotodynamic and Photothermal Therapy | Ranjbari F, Fathi F | 10.2174/0118715206295598240215112910 |
| 38411747 | Effectiveness and reliability of hypnosis in stereotaxy: a randomized study | Chiuve SC, Momjian S, Wolff A, Corniola MV | 10.1007/s00701-024-05943-0 |
| 38426022 | A voxel-level resting-state fMRI study on patients with alcohol use disordersbased on a power spectrum slope analysis method | Ruan X, Song Z, Yu T, Chen J | 10.3389/fnins.2024.1323741 |
| 38407931 | Suppressing Carrier Recombination in BiVO(4)/PEDOT:PSS Heterojunction forHigh-Performance Photodetector | Liu Z, Li J, ..., Fang H | 10.1021/acs.jpclett.4c00148 |
| 38423282 | Neonatal Nucleus Accumbens Microstructure Modulates Individual Susceptibility toPreconception Maternal Stress in Relation to Externalizing Behaviors | Chan SY, Low XZ, ..., Tan AP | 10.1016/j.jaac.2023.12.011 |
| 38408448 | Association between perceived stress and motoric cognitive risk syndrome in anelderly population: Rugao longevity and ageing study | Cao YF, Shi GP, ..., Wang XF | 10.1159/000537937 |
| 38429898 | Ionic Solvent Shell Drives Electroactuation in Organic Mixed Ionic-ElectronicConductors | Bonafe F, Decataldo F, Cramer T, Fraboni B | 10.1002/advs.202308746 |
| 38429635 | Associations of perceived stress with loneliness and depressive symptoms: themediating role of sleep quality | Wang X, Cao X, ..., Lu Y | 10.1186/s12888-024-05609-2 |